Original Paper

Polymer Bulletin

, Volume 70, Issue 5, pp 1647-1657

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Molecularly imprinted hydrogels for application in aqueous environment

  • Anna Korytkowska-WałachAffiliated withDepartment of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology Email author 


Molecularly imprinted thermoresponsive hydrogels for dopamine recognition were synthesized using N-isopropylacrylamide as the temperature-sensitive element, methacrylic acid or itaconic acid as functional monomer and N,N’-methylenebisacrylamide or ethylene glycol dimethacrylate as crosslinking agent. The stoichiometry of the template–functional monomer prepolymerization complexes was determined by 1H NMR experiments according to the Job method of continuous variation as well as signal line width analysis. It was found that dopamine hydrochloride forms complexes with methacrylic acid and itaconic acid with 1:3 and 2:3 template to functional monomer stoichiometry, respectively. Hydrogels composed of itaconic acid and with appropriate template content revealed the highest efficiency of imprinting process and relatively high selectivity of dopamine hydrochloride rebinding in water near the phase transition temperature.


Molecular imprinting Prepolymerization complex Dopamine Hydrogels Thermosensitive polymers