Journal of Mathematical Biology

, Volume 66, Issue 6, pp 1209–1240

A model of erythropoiesis in adults with sufficient iron availability


  • Doris H. Fuertinger
    • Institute for Mathematics and Scientific ComputingUniversity of Graz
    • Institute for Mathematics and Scientific ComputingUniversity of Graz
  • Stephan Thijssen
    • Renal Research Institute New York
  • Nathan W. Levin
    • Renal Research Institute New York
  • Peter Kotanko
    • Renal Research Institute New York

DOI: 10.1007/s00285-012-0530-0

Cite this article as:
Fuertinger, D.H., Kappel, F., Thijssen, S. et al. J. Math. Biol. (2013) 66: 1209. doi:10.1007/s00285-012-0530-0


In this paper we present a model for erythropoiesis under the basic assumption that sufficient iron availability is guaranteed. An extension of the model including a sub-model for the iron dynamics in the body is topic of present research efforts. The model gives excellent results for a number of important situations: recovery of the red blood cell mass after blood donation, adaptation of the number of red blood cells to changes in the altitude of residence and, most important, the reaction of the body to different administration regimens of erythropoiesis stimulating agents, as for instance in the case of pre-surgical administration of Epoetin-α. The simulation results concerning the last item show that choosing an appropriate administration regimen can reduce the total amount of the administered drug considerably. The core of the model consists of structured population equations for the different cell populations which are considered. A key feature of the model is the incorporation of neocytolysis.


ErythropoiesisNeocytolysisStructured population models

Mathematics Subject Classification


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© Springer-Verlag 2012