Cooperative interaction between Cra and Fnr in the regulation of the cydAB operon of Escherichia coli
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- Ramseier, T.M., Chien, S.Y. & Saier, M.H. Current Microbiology (1996) 33: 270. doi:10.1007/s002849900112
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In vivo and in vitro experiments are reported demonstrating that the catabolite repressoractivator (Cra) protein (formerly designated FruR) regulates expression of the cydAB operon of Escherichia coli encoding cytochrome d oxidase. The Fnr protein is required for Cra-mediated transcriptional control, but the ArcA protein antagonizes the response to Cra. The results establish that Fnr, ArcA, and Cra exert their effects in an interdependent fashion.