Current Microbiology

, Volume 56, Issue 3, pp 229–235

Isolation, Antimicrobial Activity, and Metabolites of Fungus Cladosporium sp. Associated with Red Alga Porphyra yezoensis

  • Ling Ding
  • Song Qin
  • Fuchao Li
  • Xiaoyuan Chi
  • Hartmut Laatsch
Article

DOI: 10.1007/s00284-007-9063-y

Cite this article as:
Ding, L., Qin, S., Li, F. et al. Curr Microbiol (2008) 56: 229. doi:10.1007/s00284-007-9063-y

Abstract

Cladosporium sp. isolate N5 was isolated as a dominant fungus from the healthy conchocelis of Porphyra yezoensis. In the re-infection test, it did not cause any pathogenic symptoms in the alga. Twenty-one cultural conditions were chosen to test its antimicrobial activity in order to obtain the best condition for large-scale fermentation. Phenylacetic acid, p-hydroxyphenylethyl alcohol, and l-ß-phenyllactic acid were isolated from the crude extract as strong antimicrobial compounds and they are the first reported secondary metabolites for the genus Cladosporium. In addition, the Cladosporium sp. produced the reported Porphyrayezoensis growth regulators phenylacetic acid and p-hydroxyphenylacetic acid. No cytotoxicity was found in the brine shrimp lethality test, which indicated that the environmental-friendly Cladosporium sp. could be used as a potential biocontrol agent to protect the alga from pathogens.

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Ling Ding
    • 1
    • 2
  • Song Qin
    • 1
  • Fuchao Li
    • 1
  • Xiaoyuan Chi
    • 1
  • Hartmut Laatsch
    • 3
  1. 1.Institute of OceanologyChinese Academy of SciencesShandongChina
  2. 2.Graduate School of Chinese Academy of SciencesBeijingChina
  3. 3.Department of Organic and Biomolecular ChemistryUniversity of GöttingenGöttingenGermany