Seminars in Immunopathology

, Volume 36, Issue 2, pp 211–226

JAM-related proteins in mucosal homeostasis and inflammation

  • Anny-Claude Luissint
  • Asma Nusrat
  • Charles A. Parkos
Review

DOI: 10.1007/s00281-014-0421-0

Cite this article as:
Luissint, AC., Nusrat, A. & Parkos, C.A. Semin Immunopathol (2014) 36: 211. doi:10.1007/s00281-014-0421-0

Abstract

Mucosal surfaces are lined by epithelial cells that form a physical barrier protecting the body against external noxious substances and pathogens. At a molecular level, the mucosal barrier is regulated by tight junctions (TJs) that seal the paracellular space between adjacent epithelial cells. Transmembrane proteins within TJs include junctional adhesion molecules (JAMs) that belong to the cortical thymocyte marker for Xenopus family of proteins. JAM family encompasses three classical members (JAM-A, JAM-B, and JAM-C) and related molecules including JAM4, JAM-like protein, Coxsackie and adenovirus receptor (CAR), CAR-like membrane protein and endothelial cell-selective adhesion molecule. JAMs have multiple functions that include regulation of endothelial and epithelial paracellular permeability, leukocyte recruitment during inflammation, angiogenesis, cell migration, and proliferation. In this review, we summarize the current knowledge regarding the roles of the JAM family members in the regulation of mucosal homeostasis and leukocyte trafficking with a particular emphasis on barrier function and its perturbation during pathological inflammation.

Keywords

JAMs Tight junction Leukocyte trafficking Inflammatory bowel disease 

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Anny-Claude Luissint
    • 1
  • Asma Nusrat
    • 1
  • Charles A. Parkos
    • 1
  1. 1.Epithelial pathobiology and mucosal inflammation research unit, Department of Pathology and Laboratory MedicineEmory UniversityAtlantaUSA

Personalised recommendations