Seminars in Immunopathology

, Volume 35, Issue 2, pp 151–161

Resolution of inflammation as a novel chemopreventive strategy

Review

DOI: 10.1007/s00281-013-0363-y

Cite this article as:
Lee, HN., Na, HK. & Surh, YJ. Semin Immunopathol (2013) 35: 151. doi:10.1007/s00281-013-0363-y

Abstract

Acute inflammation, a physiologic response to protect cells from microbial infection and other noxious stimuli, is automatically terminated by endogenous anti-inflammatory and pro-resolving mediators to restore homeostatic conditions. However, if timely resolution of inflammation is failed, inflammation persists and can progress to a chronic inflammation which has long been thought as a predisposing factor to carcinogenesis. Excessive and pathologic inflammation causes DNA damage, genomic instability, epigenetic dysregulation, and alteration of intracellular signaling, all of which are involved in neoplastic transformation. To prevent chronic inflammation and resulting inflammation-promoted cancer development, understanding the process that resolves inflammation is essential. Resolution of inflammation is an active coordinated process regulated by distinct anti-inflammatory and pro-resolving endogenous lipid mediators, such as resolvins and lipoxins. The role of pro-inflammatory signaling in carcinogenesis has become more and more evident and well characterized, but the potential role of pro-resolving mediators in cancer prevention remains still elusive. In searching for an efficacious way to prevent chronic inflammation-associated cancer, the pro-resolving signal transduction pathways and their regulators should be unraveled.

Keywords

Cancer Chemoprevention Inflammation-associated carcinogenesis Lipid mediators Lipid mediator class switching Prostaglandins Resolution of inflammation Resolvins 

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Tumor Microenvironment Global Core Research Center, College of PharmacySeoul National UniversitySeoulSouth Korea
  2. 2.Department of Food and NutritionSungshin Women’s UniversitySeoulSouth Korea
  3. 3.WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and TechnologySeoul National UniversitySeoulSouth Korea
  4. 4.Cancer Research InstituteSeoul National UniversitySeoulSouth Korea

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