Seminars in Immunopathology

, Volume 35, Issue 1, pp 73–85

Autoimmune manifestations in viral hepatitis


DOI: 10.1007/s00281-012-0328-6

Cite this article as:
Vergani, D. & Mieli-Vergani, G. Semin Immunopathol (2013) 35: 73. doi:10.1007/s00281-012-0328-6


Infections by the viruses responsible for hepatitis B, C and D are accompanied by a number of immunopathological manifestations. A link between infection and autoimmunity is particularly well documented for the hepatitis C virus. Immunopathological manifestations range from production of autoantibodies to overt autoimmune disease, including thyroiditis and autoimmune hepatitis, and to immune-complex-mediated disorders, including cryoglobulinaemia, glomerulonephritis and vasculitis. Several of these manifestations improve with successful antiviral treatment, directly incriminating the virus in their pathogenesis. Mechanisms considered responsible for hepatitis virus-related immunopathology, including molecular mimicry, impairment of regulatory T cells and activation of B lymphocytes, will be examined in this review.


Hepatitis CHepatitis BHepatitis DAutoimmunityImmune complex diseaseMolecular mimicryRegulatory T cellsB lymphocyte activation

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Institute of Liver Studies and Paediatric Liver, GI & Nutrition Centre, King’s College HospitalKing’s College London School of MedicineLondonUK
  2. 2.Institute of Liver StudiesKing’s College HospitalLondonUK