Seminars in Immunopathology

, Volume 34, Issue 5, pp 715-731

First online:

Eosinophilic gastrointestinal diseases—clinically diverse and histopathologically confounding

  • Seema AcevesAffiliated withDivision of Allergy, Immunology, Departments of Pediatrics and Medicine, University of California, San DiegoRady Children’s Hospital
  • , Ikuo HiranoAffiliated withDivision of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine
  • , Glenn T. FurutaAffiliated withDepartment of Pediatrics, University of Colorado Denver School of Medicine Digestive Health Institute Gastrointestinal Eosinophilic Diseases Program Mucosal Inflammation Program Children’s Hospital Colorado Email author 
  • , Margaret H. CollinsAffiliated withDepartment of Pathology, University of CincinnatiCincinnati Children’s Hospital Medical Center

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Eosinophilic gastrointestinal diseases are a group of chronic diseases characterized by a range of symptoms caused by eosinophilic inflammation of various parts of the gastrointestinal tract. Other causes for eosinophilia need to be ruled out prior to making the diagnosis of EGIDs. The most common form of EGID is eosinophilic esophagitis (EoE), an antigen-driven disease that afflicts children and adults and has been identified across the world. Histological features include dense eosinophilia of the esophageal mucosa, eosinophil degranulation, eosinophil microabscess formation, and other features of epithelial inflammation including basal zone hyperplasia and rete pege elongation. Treatments include dietary exclusions and topical corticosteroids.


Eosinophilic esophagitis Gastrointestinal allergy Esophagitis