Seminars in Immunopathology

, Volume 34, Issue 5, pp 715–731

Eosinophilic gastrointestinal diseases—clinically diverse and histopathologically confounding


  • Seema Aceves
    • Division of Allergy, Immunology, Departments of Pediatrics and MedicineUniversity of California, San Diego
    • Rady Children’s Hospital
  • Ikuo Hirano
    • Division of Gastroenterology, Department of MedicineNorthwestern University Feinberg School of Medicine
    • Department of PediatricsUniversity of Colorado Denver School of Medicine Digestive Health Institute Gastrointestinal Eosinophilic Diseases Program Mucosal Inflammation Program Children’s Hospital Colorado
  • Margaret H. Collins
    • Department of PathologyUniversity of Cincinnati
    • Cincinnati Children’s Hospital Medical Center

DOI: 10.1007/s00281-012-0324-x

Cite this article as:
Aceves, S., Hirano, I., Furuta, G.T. et al. Semin Immunopathol (2012) 34: 715. doi:10.1007/s00281-012-0324-x


Eosinophilic gastrointestinal diseases are a group of chronic diseases characterized by a range of symptoms caused by eosinophilic inflammation of various parts of the gastrointestinal tract. Other causes for eosinophilia need to be ruled out prior to making the diagnosis of EGIDs. The most common form of EGID is eosinophilic esophagitis (EoE), an antigen-driven disease that afflicts children and adults and has been identified across the world. Histological features include dense eosinophilia of the esophageal mucosa, eosinophil degranulation, eosinophil microabscess formation, and other features of epithelial inflammation including basal zone hyperplasia and rete pege elongation. Treatments include dietary exclusions and topical corticosteroids.


Eosinophilic esophagitisGastrointestinal allergyEsophagitis

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© Springer-Verlag 2012