Seminars in Immunopathology

, Volume 34, Issue 4, pp 523–540

The adaptive immune response in celiac disease

Review

DOI: 10.1007/s00281-012-0314-z

Cite this article as:
Qiao, SW., Iversen, R., Ráki, M. et al. Semin Immunopathol (2012) 34: 523. doi:10.1007/s00281-012-0314-z

Abstract

Compared to other human leukocyte antigen (HLA)-associated diseases such as type 1 diabetes, multiple sclerosis, and rheumatoid arthritis, fundamental aspects of the pathogenesis in celiac disease are relatively well understood. This is mostly because the causative antigen in celiac disease—cereal gluten proteins—is known and the culprit HLA molecules are well defined. This has facilitated the dissection of the disease-relevant CD4+ T cells interacting with the disease-associated HLA molecules. In addition, celiac disease has distinct antibody responses to gluten and the autoantigen transglutaminase 2, which give strong handles to understand all sides of the adaptive immune response leading to disease. Here we review recent developments in the understanding of the role of T cells, B cells, and antigen-presenting cells in the pathogenic immune response of this instructive disorder.

Keywords

Celiac disease Gluten T cells B cells Antigen-presenting cells 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Department of Immunology and Centre for Immune RegulationUniversity of Oslo, Oslo University Hospital—RikshospitaletOsloNorway
  2. 2.Department of PathologyOslo University Hospital—RikshospitaletOsloNorway