Seminars in Immunopathology

, Volume 34, Issue 3, pp 365–382

Glycosylation of IgA1 and pathogenesis of IgA nephropathy

  • Jan Novak
  • Bruce A. Julian
  • Jiri Mestecky
  • Matthew B. Renfrow
Review

DOI: 10.1007/s00281-012-0306-z

Cite this article as:
Novak, J., Julian, B.A., Mestecky, J. et al. Semin Immunopathol (2012) 34: 365. doi:10.1007/s00281-012-0306-z

Abstract

IgA nephropathy, described in 1968 as IgA-IgG immune-complex disease, is an autoimmune disease. Galactose-deficient IgA1 is recognized by unique autoantibodies, resulting in the formation of pathogenic immune complexes that ultimately induce glomerular injury. Thus, formation of the galactose-deficient IgA1-containing immune complexes is a critical factor in the pathogenesis of IgA nephropathy. Studies of molecular defects of IgA1 can define new biomarkers specific for IgA nephropathy that can be developed into clinical assays to aid in the diagnosis, assessment of prognosis, and monitoring of disease progression.

Keywords

IgA nephropathyIgA1O-glycansHigh-resolution mass spectrometryMeasangial cells

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Jan Novak
    • 1
    • 2
  • Bruce A. Julian
    • 1
  • Jiri Mestecky
    • 1
  • Matthew B. Renfrow
    • 1
  1. 1.University of Alabama at BirminghamBirminghamUSA
  2. 2.Department of MicrobiologyUniversity of Alabama at BirminghamBirminghamUSA