Review Article

Seminars in Immunopathology

, Volume 34, Issue 3, pp 401-413

Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases

  • Motohiro KobayashiAffiliated withDepartment of Molecular Pathology, Shinshu University Graduate School of Medicine
  • , Hitomi HoshinoAffiliated withDepartment of Molecular Pathology, Shinshu University Graduate School of MedicineDepartment of Alzheimer’s Disease Research, National Institute for Longevity Science
  • , Kenichi SuzawaAffiliated withDepartment of Molecular Pathology, Shinshu University Graduate School of Medicine
  • , Yasuhiro SakaiAffiliated withDepartment of Molecular Pathology, Shinshu University Graduate School of Medicine
  • , Jun NakayamaAffiliated withDepartment of Molecular Pathology, Shinshu University Graduate School of Medicine
  • , Minoru FukudaAffiliated withTumor Microenvironment Program, Cancer Research Center, Sanford-Burnham Medical Research Institute Email author 

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Abstract

Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin α4β7 ligand mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expressed on high endothelial venules (HEVs) and HEV-like vessels. In this review, we discuss these two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases with reference to our and others’ previously published works. We also describe a recently developed recombinant integrin α4β7 heterodimeric IgG chimera that can be used as an immunohistochemical reagent to stain functional MAdCAM-1.

Keywords

Gastrointestinal tract Chronic inflammation High endothelial venule (HEV) Peripheral lymph node addressin (PNAd) Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)