Seminars in Immunopathology

, Volume 34, Issue 3, pp 401–413

Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases

  • Motohiro Kobayashi
  • Hitomi Hoshino
  • Kenichi Suzawa
  • Yasuhiro Sakai
  • Jun Nakayama
  • Minoru Fukuda
Review Article

DOI: 10.1007/s00281-012-0302-3

Cite this article as:
Kobayashi, M., Hoshino, H., Suzawa, K. et al. Semin Immunopathol (2012) 34: 401. doi:10.1007/s00281-012-0302-3

Abstract

Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin α4β7 ligand mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expressed on high endothelial venules (HEVs) and HEV-like vessels. In this review, we discuss these two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases with reference to our and others’ previously published works. We also describe a recently developed recombinant integrin α4β7 heterodimeric IgG chimera that can be used as an immunohistochemical reagent to stain functional MAdCAM-1.

Keywords

Gastrointestinal tract Chronic inflammation High endothelial venule (HEV) Peripheral lymph node addressin (PNAd) Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Motohiro Kobayashi
    • 1
  • Hitomi Hoshino
    • 1
    • 2
  • Kenichi Suzawa
    • 1
  • Yasuhiro Sakai
    • 1
  • Jun Nakayama
    • 1
  • Minoru Fukuda
    • 3
  1. 1.Department of Molecular PathologyShinshu University Graduate School of MedicineMatsumotoJapan
  2. 2.Department of Alzheimer’s Disease ResearchNational Institute for Longevity ScienceObuJapan
  3. 3.Tumor Microenvironment Program, Cancer Research CenterSanford-Burnham Medical Research InstituteLa JollaUSA