Seminars in Immunopathology

, Volume 32, Issue 4, pp 363–372

Drosophila as a model system to study autophagy


DOI: 10.1007/s00281-010-0223-y

Cite this article as:
Zirin, J. & Perrimon, N. Semin Immunopathol (2010) 32: 363. doi:10.1007/s00281-010-0223-y


Originally identified as a response to starvation in yeast, autophagy is now understood to fulfill a variety of roles in higher eukaryotes, from the maintenance of cellular homeostasis to the cellular response to stress, starvation, and infection. Although genetics and biochemical studies in yeast have identified many components involved in autophagy, the findings that some of the essential components of the yeast pathway are missing in higher organisms underscore the need to study autophagy in more complex systems. This review focuses on the use of the fruitfly, Drosophila melanogaster as a model system for analysis of autophagy. Drosophila is an organism well-suited for genetic analysis and represents an intermediate between yeast and mammals with respect to conservation of the autophagy machinery. Furthermore, the complex biology and physiology of Drosophila presents an opportunity to model human diseases in a tissue specific and analogous context.


DrosophilaAutophagyAtgModel system

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Department of GeneticsHarvard Medical SchoolBostonUSA
  2. 2.Howard Hughes Medical InstituteHarvard Medical SchoolBostonUSA