Seminars in Immunopathology

, Volume 33, Issue 1, pp 67–87

Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease

  • John P. Driver
  • David V. Serreze
  • Yi-Guang Chen
Review

DOI: 10.1007/s00281-010-0204-1

Cite this article as:
Driver, J.P., Serreze, D.V. & Chen, Y. Semin Immunopathol (2011) 33: 67. doi:10.1007/s00281-010-0204-1

Abstract

For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type 1 diabetes (T1D). However, while sharing many similarities, it is becoming increasingly appreciated that there are also some differences in the immunopathogenic basis of T1D development between humans and NOD mice. This review will focus on aspects of T1D development in NOD mice that are similar and different from that in humans.

Keywords

Type 1 diabetesNOD miceImmunological toleranceGenetics

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • John P. Driver
    • 1
  • David V. Serreze
    • 1
  • Yi-Guang Chen
    • 1
  1. 1.The Jackson LaboratoryBar HarborUSA