Review

Seminars in Immunopathology

, Volume 32, Issue 1, pp 79-90

First online:

Th17 cytokines and vaccine-induced immunity

  • Yinyao LinAffiliated withDepartment of Pediatrics and Immunology, University of Pittsburgh School of Medicine
  • , Samantha R. SlightAffiliated withDepartment of Pediatrics and Immunology, University of Pittsburgh School of Medicine
  • , Shabaana A. KhaderAffiliated withDepartment of Pediatrics and Immunology, University of Pittsburgh School of MedicineChildren’s Hospital of Pittsburgh Email author 

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Abstract

T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in primary immune responses against infections is well documented, there is growing evidence that the Th17 lineage maybe critical for vaccine-induced memory immune responses against infectious diseases. Here, we summarize recent progress in our understanding of the role of IL-17 in vaccine-induced immunity.

Keywords

Th17 Infection Vaccine-induced immunity