Seminars in Immunopathology

, Volume 31, Issue 2, pp 145–149

The mucosal firewalls against commensal intestinal microbes

  • Andrew J. Macpherson
  • Emma Slack
  • Markus B. Geuking
  • Kathy D. McCoy
Review

DOI: 10.1007/s00281-009-0174-3

Cite this article as:
Macpherson, A.J., Slack, E., Geuking, M.B. et al. Semin Immunopathol (2009) 31: 145. doi:10.1007/s00281-009-0174-3

Abstract

Mammals coexist with an extremely dense microbiota in the lower intestine. Despite the constant challenge of small numbers of microbes penetrating the intestinal surface epithelium, it is very unusual for these organisms to cause disease. In this review article, we present the different mucosal firewalls that contain and allow mutualism with the intestinal microbiota.

Keywords

Mucosal firewallsCommensal intestinal microbesLower intestineMicrobiotaHost–microbial relationship

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Andrew J. Macpherson
    • 1
  • Emma Slack
    • 1
  • Markus B. Geuking
    • 1
  • Kathy D. McCoy
    • 1
  1. 1.DKF, Maurice Müller Laboratories, Department of Visceral Surgery and MedicineUniversity of BernBernSwitzerland