Seminars in Immunopathology

, Volume 30, Issue 4, pp 457–477

Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: pre-clinical and clinical approaches

  • Ann P. Chidgey
  • Natalie Seach
  • Jarrod Dudakov
  • Maree V. Hammett
  • Richard L. Boyd
Review

DOI: 10.1007/s00281-008-0140-5

Cite this article as:
Chidgey, A.P., Seach, N., Dudakov, J. et al. Semin Immunopathol (2008) 30: 457. doi:10.1007/s00281-008-0140-5

Abstract

Poor immune recovery is characteristic of bone marrow transplantation and leads to high levels of morbidity and mortality. The primary underlying cause is a compromised thymic function, resulting from age-induced atrophy and further compounded by the damaging effects of cytoablative conditioning regimes on thymic epithelial cells (TEC). Several strategies have been proposed to enhance T cell reconstitution. Some, such as the use of single biological agents, are currently being tested in clinical trials. However, a more rational approach to immune restoration will be to leverage the evolving repertoire of new technologies. Specifically, the combined targeting of TEC, thymocytes and peripheral T cells, together with the bone marrow niches, promises a more strategic clinical therapeutic platform.

Keywords

Thymus Ageing Regeneration Stem cells Immune reconstitution 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Ann P. Chidgey
    • 1
  • Natalie Seach
    • 1
  • Jarrod Dudakov
    • 1
  • Maree V. Hammett
    • 1
  • Richard L. Boyd
    • 1
  1. 1.Monash Immunology and Stem Cell Laboratories, Building 75, STRIPMonash UniversityMelbourneAustralia

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