Reconstitution of the immune system after hematopoietic stem cell transplantation in humans
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- Storek, J., Geddes, M., Khan, F. et al. Semin Immunopathol (2008) 30: 425. doi:10.1007/s00281-008-0132-5
Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery.