Seminars in Immunopathology

, 30:425

Reconstitution of the immune system after hematopoietic stem cell transplantation in humans

  • Jan Storek
  • Michelle Geddes
  • Faisal Khan
  • Bertrand Huard
  • Claudine Helg
  • Yves Chalandon
  • Jakob Passweg
  • Eddy Roosnek
Review

DOI: 10.1007/s00281-008-0132-5

Cite this article as:
Storek, J., Geddes, M., Khan, F. et al. Semin Immunopathol (2008) 30: 425. doi:10.1007/s00281-008-0132-5

Abstract

Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery.

Keywords

Hematopoietic stem cell transplantationImmunityImmune deficiencyThymusHomeostasis

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Jan Storek
    • 1
  • Michelle Geddes
    • 1
  • Faisal Khan
    • 1
  • Bertrand Huard
    • 2
  • Claudine Helg
    • 2
  • Yves Chalandon
    • 2
  • Jakob Passweg
    • 2
  • Eddy Roosnek
    • 2
    • 3
  1. 1.Division of Hematology and Hematologic Malignancies, Department of MedicineUniversity of CalgaryCalgaryCanada
  2. 2.Division of Hematology, Department of Internal MedicineGeneva University Hospitals and University of GenevaGenevaSwitzerland
  3. 3.Division of HematologyHUGGeneva 14Switzerland