Seminars in Immunopathology

, Volume 30, Issue 3, pp 315–327

Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract

  • Kazuhito Rokutan
  • Tsukasa Kawahara
  • Yuki Kuwano
  • Kumiko Tominaga
  • Keisei Nishida
  • Shigetada Teshima-Kondo
Review

DOI: 10.1007/s00281-008-0124-5

Cite this article as:
Rokutan, K., Kawahara, T., Kuwano, Y. et al. Semin Immunopathol (2008) 30: 315. doi:10.1007/s00281-008-0124-5

Abstract

Chronic inflammation caused by Helicobacter pylori infection or inflammatory bowel disease (IBD) is closely linked to cancer development. Innate immune abnormalities and enhanced production of reactive oxygen species through a phagocyte NADPH oxidase (Nox2) are key issues in understanding the pathogenesis of inflammation-dependent carcinogenesis. Besides Nox2, functionally distinct homologues (Nox1, Nox3, Nox4, Nox5, Duox1, and Duox2) have been identified. Nox1 and Duox2 are highly expressed in the gastrointestinal tract. Although the functional roles of Nox/Duox in the gastrointestinal tract are still unclear, we will review their potential roles in the gastrointestinal immunopathology, particularly in H. pylori-induced inflammation, IBD, and malignancy.

Keywords

Nox1 Nox2 Duox2 Innate immunity Inflammation Carcinogenesis 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Kazuhito Rokutan
    • 1
  • Tsukasa Kawahara
    • 1
  • Yuki Kuwano
    • 1
  • Kumiko Tominaga
    • 1
  • Keisei Nishida
    • 1
  • Shigetada Teshima-Kondo
    • 1
  1. 1.Department of Stress Science, Institute of Health BiosciencesUniversity of Tokushima Graduate SchoolTokushimaJapan