Seminars in Immunopathology

, Volume 30, Issue 3, pp 291–300

NOX enzymes and Toll-like receptor signaling

  • Eric Ogier-Denis
  • Sanae Ben Mkaddem
  • Alain Vandewalle
Review

DOI: 10.1007/s00281-008-0120-9

Cite this article as:
Ogier-Denis, E., Mkaddem, S.B. & Vandewalle, A. Semin Immunopathol (2008) 30: 291. doi:10.1007/s00281-008-0120-9

Abstract

Invading microorganisms are recognized by the host innate immune system through pattern recognition receptors. Among these receptors, Toll-like receptors (TLRs) are able to sense the molecular signatures of microbial pathogens, protozoa, fungi, and virus and activate proinflammatory signaling cascades. In addition to their role in bacterial killing by phagocytes, reactive oxygen species generated by NADPH oxidase (NOX) homologues also play key roles in signaling and host defense in a variety of cell types. Recent studies have demonstrated a link between TLR activation and NOX homologues following microbial recognition highlighting their important role in the innate immune response and host defense.

Keywords

NADPH oxidasesReactive oxygen speciesToll-like receptorsInnate immunityHost defense

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Eric Ogier-Denis
    • 1
    • 2
  • Sanae Ben Mkaddem
    • 1
    • 2
  • Alain Vandewalle
    • 1
    • 2
  1. 1.INSERM, U773Centre de Recherche Biomédicale Bichat BeaujonParisFrance
  2. 2.Université Paris 7-Denis DiderotParisFrance