Seminars in Immunopathology

, Volume 30, Issue 1, pp 41–51

Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malaria

  • Catherine Ropert
  • Bernardo S. Franklin
  • Ricardo T. Gazzinelli
Review

DOI: 10.1007/s00281-007-0103-2

Cite this article as:
Ropert, C., Franklin, B.S. & Gazzinelli, R.T. Semin Immunopathol (2008) 30: 41. doi:10.1007/s00281-007-0103-2

Abstract

Toll-like receptors (TLRs) are important to initiate the innate immune response to a wide variety of pathogens. The protective role of TLRs during infection with protozoan parasites has been established. In this regard, malaria represents an exception where activation of TLRs seems to be deleterious to the host. In this article, we review the recent findings indicating the contrasting role of Myeloid Differentiation Primary-Response gene 88 (MyD88) and TLRs during malaria and infection with other protozoa. These findings suggest that MyD88 may represent an Achilles’ heel during Plasmodium infection.

Keywords

Innate immunityToll-like receptorsMyD88Protozoan parasitesCytokinesDendritic cells

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Catherine Ropert
    • 1
  • Bernardo S. Franklin
    • 1
  • Ricardo T. Gazzinelli
    • 1
    • 2
    • 3
  1. 1.Laboratory of Immunopathology, René Rachou InstituteFIOCRUZBelo HorizonteBrazil
  2. 2.Department of Biochemistry and Immunology, Institute of Biological SciencesFederal University of Minas GeraisBelo HorizonteBrazil
  3. 3.Division of Infectious Disease and Immunology, Department of MedicineUniversity of Massachusetts Medical SchoolWorcesterUSA