Review

Seminars in Immunopathology

, 29:135

First online:

The role of macrophage migration inhibitory factor in maintaining the immune privilege at the fetal–maternal interface

  • Paola ViganòAffiliated withII Department of Obstetrics and Gynecology, University of Milan and Istituto Auxologico Italiano
  • , Marcella CintorinoAffiliated withDepartment of Human Pathology and Oncology, Section of Pathology, University of Siena—School of Medicine
  • , Frederick SchatzAffiliated withDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine
  • , Charles J. LockwoodAffiliated withDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine
  • , Felice ArcuriAffiliated withDepartment of Human Pathology and Oncology, Section of Pathology, University of Siena—School of Medicine Email author 

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Abstract

Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the innate and adaptive immunity affecting the response and behavior of macrophages and lymphocytes. MIF is also implicated in other fundamental cellular processes including angiogenesis and cell proliferation. Several studies examined the expression of MIF in reproductive organs and tissues and its involvement in different aspects of human and animal reproduction. The goal of this review was to summarize these findings and discuss, in particular, the role of MIF in the maintenance of the immune privilege at the human fetal–maternal interface.

Keywords

MIF Pregnancy Immunosuppression Uterine NK cells Decidual macrophages