Seminars in Immunopathology

, 29:135

The role of macrophage migration inhibitory factor in maintaining the immune privilege at the fetal–maternal interface

  • Paola Viganò
  • Marcella Cintorino
  • Frederick Schatz
  • Charles J. Lockwood
  • Felice Arcuri
Review

DOI: 10.1007/s00281-007-0074-3

Cite this article as:
Viganò, P., Cintorino, M., Schatz, F. et al. Semin Immunopathol (2007) 29: 135. doi:10.1007/s00281-007-0074-3

Abstract

Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the innate and adaptive immunity affecting the response and behavior of macrophages and lymphocytes. MIF is also implicated in other fundamental cellular processes including angiogenesis and cell proliferation. Several studies examined the expression of MIF in reproductive organs and tissues and its involvement in different aspects of human and animal reproduction. The goal of this review was to summarize these findings and discuss, in particular, the role of MIF in the maintenance of the immune privilege at the human fetal–maternal interface.

Keywords

MIFPregnancyImmunosuppressionUterine NK cellsDecidual macrophages

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Paola Viganò
    • 1
  • Marcella Cintorino
    • 2
  • Frederick Schatz
    • 3
  • Charles J. Lockwood
    • 3
  • Felice Arcuri
    • 2
  1. 1.II Department of Obstetrics and GynecologyUniversity of Milan and Istituto Auxologico ItalianoMilanItaly
  2. 2.Department of Human Pathology and Oncology, Section of PathologyUniversity of Siena—School of MedicineSienaItaly
  3. 3.Department of Obstetrics, Gynecology and Reproductive SciencesYale University School of MedicineNew HavenUSA