Springer Seminars in Immunopathology

, Volume 28, Issue 3, pp 221–230

Therapeutic immunization for HIV

  • Lindvi Gudmundsdotter
  • Anna Sjödin
  • Ann-Charlotte Boström
  • Bo Hejdeman
  • Rebecca Theve-Palm
  • Annette Alaeus
  • Knut Lidman
  • Britta Wahren
Review

DOI: 10.1007/s00281-006-0029-0

Cite this article as:
Gudmundsdotter, L., Sjödin, A., Boström, AC. et al. Springer Semin Immun (2006) 28: 221. doi:10.1007/s00281-006-0029-0

Abstract

Vaccines have entered into human clinical trials against infectious diseases and as therapies against cancer. The HIV virus establishes a latent infection at a very early stage and the T cell memory of the infected patient is rapidly destroyed. However, results of immunotherapy after DNA and protein immunization show that vaccine-induced immune responses might be present for a long period of time. Patients subjected to therapeutic immunization appear to do well, and to have a small immunological advantage, which, however, will have to be improved. The vaccine therapy should start early, while adequate reservoirs of appropriate T helper cells are available and still inducible. The DNA vaccines induce a relatively long-lived immunological memory, and gene-based immunization is effective in inducing cytotoxic CD8+ T cells and CD4+ helper cells. Protein vaccines, on the other hand, primarily give T cell help. It thus appears that DNA and protein approaches to HIV immunization complement each other. A surprisingly broad reactivity to peptides from different subtypes of HIV was identified in individuals infected with several subtypes of HIV.

Keywords

HIV-1ImmunotherapyDNA immunizationProtein immunizationCross reactivity

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Lindvi Gudmundsdotter
    • 1
  • Anna Sjödin
    • 1
  • Ann-Charlotte Boström
    • 1
    • 2
  • Bo Hejdeman
    • 3
  • Rebecca Theve-Palm
    • 4
  • Annette Alaeus
    • 4
  • Knut Lidman
    • 4
  • Britta Wahren
    • 1
    • 2
  1. 1.Swedish Institute for Infectious Disease ControlStockholmSweden
  2. 2.Microbiology and Tumorbiology CenterKarolinska InstituteStockholmSweden
  3. 3.Department of DermatovenereologyKarolinska University Hospital at South HospitalStockholmSweden
  4. 4.Department of Infectious DiseasesKarolinska University Hospital in SolnaStockholmSweden