Cancer Chemotherapy and Pharmacology

, Volume 40, Issue 3, pp 233–238

Dose intensity of uracil and tegafur in postoperative chemotherapy for patients with poorly differentiated gastric cancer

  • Keizo Sugimachi
  • Yoshihiko Maehara
  • Michio Ogawa
  • Teruo Kakegawa
  • Masao Tomita
ORIGINAL ARTICLE

DOI: 10.1007/s002800050652

Cite this article as:
Sugimachi, K., Maehara, Y., Ogawa, M. et al. Cancer Chemother Pharmacol (1997) 40: 233. doi:10.1007/s002800050652

Abstract

A retrospective analysis of postoperative chemotherapy had shown the continuous administration of UFT, an oral preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil (tegafur) and uracil at a molar ratio of 1:4, to be effective for poorly differentiated gastric cancer. We therefore sought to determine prospectively the effective dose of postoperative chemotherapy with UFT for patients with poorly differentiated gastric cancer following a curative resection. We determined the effect of the combined intravenous administration of mitomycin C (MMC) and oral treatment with protein-bound polysaccharide Kreha (PSK), extracted from the basidiomycete Coriolus versicolor, and UFT at a dose of either 8 mg/kg or 12 mg/kg daily for 1 year. A total of 224 patients with poorly differentiated stage II–IV gastric cancer were entered into this study after undergoing a curative resection. No differences were observed between the two treatment groups in terms of prognostic factors, the toxicity rate or the doses of the drugs prescribed, other than UFT. The higher dose of UFT in maintenance therapy led to a decrease in the recurrence rate (P < 0.05), and increases in disease-free survival and cause-specific survival (P < 0.05). UFT at 12 mg/␣kg in postoperative chemotherapy was thus found- to improve the postoperative results with no increase in toxicity for poorly differentiated gastric cancer, and is also cost-effective for outpatients.

Key words Gastric cancer   Postoperative chemotherapy   UFT   Recurrence   Prognosis 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Keizo Sugimachi
    • 1
  • Yoshihiko Maehara
    • 1
  • Michio Ogawa
    • 2
  • Teruo Kakegawa
    • 3
  • Masao Tomita
    • 4
  1. 1.Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka 812, Japan Fax 81 92 642 5482JP
  2. 2.Department of Surgery II, School of Medicine, Kumamoto University, KumamotoXX
  3. 3.Department of Surgery I, Faculty of Medicine, Kurume University, KurumeXX
  4. 4.Department of Surgery I, Faculty of Medicine, Nagasaki University, NagasakiXX

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