Phase 1/pharmacology study of intraperitoneal topotecan alone and with cisplatin: potential for consolidation in ovarian cancer
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Most ovarian cancers recur after first-line treatment. We studied the pharmacology, tolerability, and therapeutic potential of intraperitoneal (IP) topotecan, alone and with IP cisplatin.
Patients received IP topotecan 1.5 mg (flat dose) daily on days 1–5 (level 0) via IP catheter. Subsequent cohorts received IP cisplatin 50 mg/m2 on day 1 added to topotecan 1.5 mg on days 1–3 (level I), topotecan 1.25 mg on days 1–3 (level II), or topotecan 1.25 mg on days 1–5 (level III). Plasma and IP concentrations of total and lactone (E-ring closed) topotecan were measured on days 1 and 2 in cycles 1 and 2.
Sixteen patients (15 tubo-ovarian, 1 gastric cancers) were entered at levels 0 (3), I (4), II (4), or III (5). Dose-limiting neutropenias occurred in seven patients at dose levels I and III; grade 3 thrombocytopenia occurred in two at level III. Other toxicities included grade 1 hives in two, serum creatinine elevations in two, and Staphylococcus epidermidis and chemical peritonitis (one each). A median progression-free survival of 13 months was recorded among ovarian cancer patients who had minimal (6) or no residuum (3) after platinum-based induction; 5 are alive at 4 years. Topotecan’s AUC IP/AUC plasma ratios ranged from 13 to 119.
Topotecan IP for 3–5 days is tolerable; occasionally, myelosuppression is dose-limiting. Topotecan 1.25 mg (days 1–3) with IP cisplatin 50 mg/m2 (day 1) is a regimen suitable for consolidation in phase 3 trials.
- Phase 1/pharmacology study of intraperitoneal topotecan alone and with cisplatin: potential for consolidation in ovarian cancer
Cancer Chemotherapy and Pharmacology
Volume 68, Issue 2 , pp 457-463
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- Ovarian cancer
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- Author Affiliations
- 1. Department of Medical Oncology, Breast Section, Montefiore Medical Center/Albert Einstein Cancer Center, 1825 Eastchester Road, Rm. 2555, Bronx, NY, 10461, USA
- 2. Banner Health, Sun City West Clinic, 14416 West Meeker Boulevard, Sun City West, AZ, 85375, USA
- 3. NYU Cancer Institute, 550 First Avenue, BCD556, New York, NY, 10016, USA
- 4. Yale Cancer Center, PO Box 208028, New Haven, CT, 06520-8028, USA