Original Article

Cancer Chemotherapy and Pharmacology

, Volume 68, Issue 2, pp 505-511

First online:

Phase I study of LY2181308, an antisense oligonucleotide against survivin, in patients with advanced solid tumors

  • M. TaniokaAffiliated withDivision of Internal Medicine, National Cancer Center Hospital
  • , H. NokiharaAffiliated withDivision of Internal Medicine, National Cancer Center Hospital
  • , N. YamamotoAffiliated withDivision of Internal Medicine, National Cancer Center Hospital
  • , Y. YamadaAffiliated withDivision of Internal Medicine, National Cancer Center Hospital
  • , K. YamadaAffiliated withDivision of Internal Medicine, National Cancer Center Hospital
  • , Y. GotoAffiliated withDivision of Internal Medicine, National Cancer Center Hospital
  • , T. FujimotoAffiliated withEli Lilly Japan K.K.
  • , R. SekiguchiAffiliated withEli Lilly Japan K.K.
  • , K. UenakaAffiliated withEli Lilly Japan K.K.
    • , S. CalliesAffiliated withEli Lilly and Company, Erl Wood Manor
    • , T. TamuraAffiliated withDivision of Internal Medicine, National Cancer Center Hospital Email author 

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Abstract

Purpose

LY2181308 is an antisense oligonucleotide that complementarily binds to survivin mRNA and inhibits its expression in tumor tissue. This phase I dose escalation study evaluated the tolerability, pharmacokinetics, and anticancer activity of LY2181308 in Japanese.

Methods

Patients with solid tumors refractory to standard therapy received LY2181308 (400, 600, or 750 mg) as a 3-h intravenous infusion for 3 consecutive days and thereafter once a week.

Results

LY2181308 was administered to 14 patients, aged 44–73 (median 60) years. Flu-like syndrome, prolonged prothrombin time-international normalized ratio (PT-INR), thrombocytopenia, and fatigue were common reversible grade 1/2 toxicities. The dose-limiting toxicity was reversible grade 3 elevation of ALT/AST/γ-GTP in 1 patient treated at the 750-mg dose. Pharmacokinetic analysis showed a long terminal half-life of 21 days and an extensive tissue distribution of LY2181308. In 12 evaluable patients, one patient had stable disease, while the remaining 11 patients had progressive disease.

Conclusions

LY2181308 monotherapy is well tolerated up to 750 mg with a manageable toxicity, the pharmacokinetic profile warrants further evaluation of LY2181308 in combination with cytotoxic agents or radiotherapy.

Keywords

Antisense oligonucleotide Pharmacokinetics Phase I Survivin