Bevacizumab induced reversible thrombocytopenia in a patient with recurrent high-grade glioma: a case report
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- Leal, T. & Robins, H.I. Cancer Chemother Pharmacol (2010) 65: 399. doi:10.1007/s00280-009-1118-2
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We report a case of bevacizumab (BEV)-induced thrombocytopenia in a 36-year-old woman treated with BEV as a single-agent for a recurrent high-grade glioma. The thrombocytopenia was both reversible and reproducible on multiple treatment cycles. The patient has improved clinically and by brain MR imaging with single-agent BEV for approximately 7 months to date. She did not have bleeding or thromboembolic complications. Treatment delays have been 1–2 weeks relative to a conventional plan of treatment, i.e., 10 mg/kg every 2 weeks. This is a rare complication that has not been previously reported.