Cancer Chemotherapy and Pharmacology

, Volume 64, Issue 6, pp 1253–1259

Outcome of upfront combination chemotherapy followed by chemoradiation for locally advanced pancreatic adenocarcinoma

  • Michele Reni
  • S. Cereda
  • G. Balzano
  • P. Passoni
  • A. Rognone
  • A. Zerbi
  • R. Nicoletti
  • E. Mazza
  • P. G. Arcidiacono
  • V. Di Carlo
  • E. Villa
Original Article

DOI: 10.1007/s00280-009-0995-8

Cite this article as:
Reni, M., Cereda, S., Balzano, G. et al. Cancer Chemother Pharmacol (2009) 64: 1253. doi:10.1007/s00280-009-0995-8

Abstract

Purpose

The role and timing of chemotherapy and radiation for treating stage III pancreatic adenocarcinoma remains controversial.

Methods

Treatment-naive patients with stage III non-resectable pancreatic adenocarcinoma were treated with PEFG/PEXG (cisplatin, epirubicin, 5-fluorouracil (F)/capecitabine (X), gemcitabine) or PDXG (docetaxel substituting epirubicin) regimen for 6 months followed by radiotherapy (50–60 Gy) with concurrent F or X or G.

Results

Ninety-one patients were registered between April 1997 and December 2007. Forty-three patients (47%) had a partial remission and 38 (42%) had a stable disease. Thirteen patients (14%) were radically resected yielding one pathologic complete remission. Median survival (OS) was 16.2 months. Median progression-free survival was 9.9 months. Pattern of failure consisted of isolated local failure (N = 26, 35%); both local and systemic failure (N = 14, 19%); isolated systemic failure (N = 35, 47%).

Conclusion

Combination chemotherapy with four-drug regimens followed by chemoradiation was a feasible strategy showing relevant results in stage III pancreatic adenocarcinoma.

Keywords

Locally advanced pancreatic cancerChemotherapyStage III pancreatic cancerRadiotherapyPancreatic cancer

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Michele Reni
    • 1
  • S. Cereda
    • 1
  • G. Balzano
    • 2
  • P. Passoni
    • 3
  • A. Rognone
    • 1
  • A. Zerbi
    • 2
  • R. Nicoletti
    • 4
  • E. Mazza
    • 1
  • P. G. Arcidiacono
    • 5
  • V. Di Carlo
    • 2
  • E. Villa
    • 1
  1. 1.Department of OncologyS. Raffaele Scientific InstituteMilanItaly
  2. 2.Department of SurgeryS. Raffaele Scientific InstituteMilanItaly
  3. 3.Department of RadiotherapyS. Raffaele Scientific InstituteMilanItaly
  4. 4.Department of RadiologyS. Raffaele Scientific InstituteMilanItaly
  5. 5.Department of GastroenterologyS. Raffaele Scientific InstituteMilanItaly