Expression of ERCC1 and class III β-tubulin in non-small cell lung cancer patients treated with a combination of cisplatin/docetaxel and concurrent thoracic irradiation
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The expression of excision repair cross-complementation group 1 (ERCC1) is reported to be correlated with resistance to platinum-based drugs. Class III β-tubulin is reported to be correlated with resistance to taxanes.
In the present study, we evaluated whether ERCC1 and class III β-tubulin expression could be used to predict progression-free and/or overall survival in 34 patients with locally advanced non-small cell lung cancer (NSCLC) receiving concurrent chemoradiation therapy with cisplatin and docetaxel, and immunohistochemistry was used to examine the expression of these two proteins in tumor samples obtained from the patients.
Immunostaining for ERCC1 and class III β-tubulin was positive in 16 and 12 patients, respectively. A significant correlation was observed between ERCC1 expression and response to chemotherapy (P = 0.012), and between class III β-tubulin expression and histology (P = 0.029). Patients negative for ERCC1 had a significantly longer median progression-free (62.5 vs. 36 weeks, P = 0.009), but not overall (171 vs. 50.5 weeks, P = 0.208), survival than those positive for ERCC1. Expression of class III β-tubulin was not correlated with progression-free or overall survival (P = 0.563 and P = 0.265, respectively). Multivariate analysis adjusting for possible confounding factors showed that negative ERCC1 expression (hazard ratio = 3.972, P = 0.009) was a significantly favorable factor for progression-free survival.
This retrospective study indicates that immunostaining for ERCC1 may be useful for predicting survival in NSCLC patients receiving concurrent chemoradiotherapy with cisplatin and docetaxel, and can provide information critical for planning personalized chemotherapy.
- Expression of ERCC1 and class III β-tubulin in non-small cell lung cancer patients treated with a combination of cisplatin/docetaxel and concurrent thoracic irradiation
Cancer Chemotherapy and Pharmacology
Volume 64, Issue 3 , pp 565-573
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Class III β-tubulin
- Industry Sectors
- Author Affiliations
- 1. Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan
- 4. Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Japan
- 6. Department of Surgery, Kitano Hospital, Tazuke-Kofukai Medical Research Institute, Osaka, Japan
- 2. Department of Pathology, Kurume University School of Medicine, Kurume, Japan
- 5. Biostatistics Center, Kurume University, Kurume, Japan
- 3. Department of Surgery, Kurume University School of Medicine, Kurume, Japan
- 7. Department of Respiratory Medicine, National Hospital Organization, Kyushu Medical Center, Chuo-ku, Fukuoka, Japan