Cancer Chemotherapy and Pharmacology

, Volume 63, Issue 3, pp 529–533

Phase II study of 5-fluorouracil and paclitaxel in patients with gemcitabine-refractory pancreatic cancer

  • Yoon Jae Kim
  • Seungmin Bang
  • Jeong Youp Park
  • Seung Woo Park
  • Jae Bock Chung
  • Si Young Song
Original Article

DOI: 10.1007/s00280-008-0822-7

Cite this article as:
Kim, Y.J., Bang, S., Park, J.Y. et al. Cancer Chemother Pharmacol (2009) 63: 529. doi:10.1007/s00280-008-0822-7

Abstract

Purpose

There is no effective salvage regimen for failed gemcitabine-based chemotherapy. This study evaluated the efficacy and toxicity of 5-fluorouracil and paclitaxel in patients with gemcitabine-refractory pancreatic cancer.

Methods

Between January 2004 and December 2007, 28 patients with pancreatic cancer previously treated with gemcitabine-based chemotherapy were enrolled. 5-Fluorouracil 1,000 mg/m2 was infused (days 1, 2, and 3) and paclitaxel 175 mg/m2 (day 1) was administered every 4 weeks. The primary endpoint of this study was efficacy and toxicity and the secondary endpoint was time to progression and overall survival.

Results

A total of 75 cycles were given, for a mean of 2.68 cycles per patient. The response could be evaluated in 20 patients. Two patients (10%) obtained a partial response, and four patients (20%) had stable disease. The median time to progression and overall survival was 2.5 and 7.6 months, respectively.

Grade 3/4 hematological toxicity included neutropenia in six patients (21.4%), anemia in one (3.6%), and thrombocytopenia in one (3.6%). One (3.6%) patient experienced grade 4 neuropathy, and two (7.2%) patients experienced grade 3 diarrhea.

Conclusion

The 5-fluorouracil and paclitaxel combination treatment seems to be effective in patients with advanced pancreatic cancer that did not respond to a gemcitabine-based regimen.

Keywords

Pancreatic cancerPaclitaxel5-FluorouracilGemcitabine

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Yoon Jae Kim
    • 1
  • Seungmin Bang
    • 1
  • Jeong Youp Park
    • 1
  • Seung Woo Park
    • 1
  • Jae Bock Chung
    • 1
  • Si Young Song
    • 1
    • 2
  1. 1.Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of GastroenterologyYonsei University College of MedicineSeoulSouth Korea
  2. 2.Brain Korea 21 Project for Medical ScienceYonsei University College of MedicineSeoulSouth Korea