Cancer Chemotherapy and Pharmacology

, Volume 60, Issue 6, pp 821–829

Assessing the therapeutic and toxicological effects of cesium chloride following administration to nude mice bearing PC-3 or LNCaP prostate cancer xenografts

  • Jonathan C. Low
  • Kishor M. Wasan
  • Ladan Fazli
  • Andy Eberding
  • Hans Adomat
  • Emma S. Guns
Original Article

DOI: 10.1007/s00280-007-0429-4

Cite this article as:
Low, J.C., Wasan, K.M., Fazli, L. et al. Cancer Chemother Pharmacol (2007) 60: 821. doi:10.1007/s00280-007-0429-4

Abstract

Purpose

The purpose of this study was to assess the therapeutic and toxicological effects of cesium chloride (CsCl) administration in mice bearing prostate cancer tumors.

Methods

Three CsCl dose titration studies were completed in tumor-bearing and non-tumor-bearing athymic nude mice. All mice were administered either vehicle (controls), 150, 300, 600, 800, 1,000, or 1,200 mg/kg of CsCl once daily by oral gavage for 30 consecutive days. Body mass was measured daily, food and water consumption were measured every 2 days, and tumor volume was measured twice weekly. Histopathological analysis was conducted on tissues collected from each of the studies. Serum AST/ALT and creatinine were also measured.

Results

Administration of 800–1,200 mg/kg CsCl reduced PC-3 tumor growth but had no effect on LNCaP tumors. Administration of 800–1,200 mg/kg CsCl also resulted in increased water consumption, bladder crystal development, and higher prevalence of cardiac fibrin clots. An observed loss in body mass was dependent on the xenograft type and concentration of CsCl administered. CsCl did not affect serum AST/ALT and creatinine levels.

Conclusions

CsCl may have a therapeutic effect against prostate cancer, but one cannot overlook the acute toxicities also described.

Keywords

Cesium chloride Prostate cancer PC-3 tumor LNCaP tumor Acute toxicity 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Jonathan C. Low
    • 1
    • 2
  • Kishor M. Wasan
    • 2
  • Ladan Fazli
    • 1
  • Andy Eberding
    • 1
  • Hans Adomat
    • 1
  • Emma S. Guns
    • 1
  1. 1.Urologic SciencesThe Prostate Center at Vancouver General HospitalVancouverCanada
  2. 2.Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical SciencesUniversity of British ColumbiaVancouverCanada

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