Cancer Chemotherapy and Pharmacology

, Volume 59, Issue 3, pp 375–381

Intraoperative versus postoperative electrochemotherapy in high grade soft tissue sarcomas: a preliminary study in a spontaneous feline model

  • Enrico P. Spugnini
  • Alfonso Baldi
  • Bruno Vincenzi
  • Franco Bongiorni
  • Corrado Bellelli
  • Gennaro Citro
  • Alessandro Porrello
Original Article

DOI: 10.1007/s00280-006-0281-y

Cite this article as:
Spugnini, E.P., Baldi, A., Vincenzi, B. et al. Cancer Chemother Pharmacol (2007) 59: 375. doi:10.1007/s00280-006-0281-y

Abstract

Feline soft tissue sarcomas are spontaneous, rapidly growing, and aggressive neoplasms that mimic their human counterpart. The purpose of this study was to evaluate the feasibility and efficacy of electrochemotherapy (ECT) in an adjuvant fashion for the treatment of feline sarcomas, and the possibility of repeated treatments in the case of recurrence. Cats with fibrosarcoma (FSA) were assigned to receive surgery or surgery plus ECT. Feline patients recruited in the ECT study were enrolled in a microscopic arm (39 patients) or a macroscopic arm (19 patients) on the basis of their tumor status (absence or presence of gross disease). Patients received local injection of bleomycin followed by bursts of eight biphasic pulses at a voltage of 1,300 V/cm for postoperative and of 800 V/cm for intraoperative treatments. The median time to recurrence was 4 months for cats treated with surgery alone, 19 months for the postoperative cohort, and 12 months for the intraoperative group. Moreover, ten patients with recurring neoplasms were retreated and experienced responses lasting 6 to 28+ months. Side effects were minimal. Of interest, the metastatic rate (1.7%) in our patients was negligible: only one cat had distant spread. The results suggest that ECT is a well tolerated and potentially useful addition to surgery in controlling high-grade sarcomas. On the basis of these results, additional evaluations are warranted in pets and in humans.

Keywords

Adjuvant Bleomycin Cat Electrochemotherapy Sarcoma 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Enrico P. Spugnini
    • 1
  • Alfonso Baldi
    • 1
  • Bruno Vincenzi
    • 2
  • Franco Bongiorni
    • 3
  • Corrado Bellelli
    • 4
  • Gennaro Citro
    • 1
  • Alessandro Porrello
    • 5
  1. 1.SAFU DepartmentRegina Elena Cancer InstituteRomeItaly
  2. 2.Medical OncologyUniversity Campus Bio-MedicoRomeItaly
  3. 3.Ambulatorio Dr. BongiorniRomeItaly
  4. 4.Zoospedale FlaminoRomeItaly
  5. 5.Molecular Oncogenesis Laboratory, Regina Elena Cancer InstituteCenter for Experimental ResearchRomeItaly

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