Cancer Chemotherapy and Pharmacology

, Volume 59, Issue 1, pp 35–42

Early intervention with epoetin beta prevents severe anaemia in patients with solid tumours receiving platinum-based chemotherapy: results of the NeoPrevent study

  • Javier de Castro
  • Amalio Ordóñez
  • Dolores Isla
  • Alfredo Sánchez
  • Antonio Arrivi
  • José Luis Manzano
  • Manuel González Barón
Original Article

DOI: 10.1007/s00280-006-0251-4

Cite this article as:
de Castro, J., Ordóñez, A., Isla, D. et al. Cancer Chemother Pharmacol (2007) 59: 35. doi:10.1007/s00280-006-0251-4

Abstract

Background

Anaemia is common during platinum-based chemotherapy. This study aimed to evaluate the efficacy and safety of epoetin beta in the prevention of severe anaemia in patients with solid tumours receiving concomitant platinum therapy.

Patients and methods

In this open-label, single-arm study, patients (= 255) with solid tumours and haemoglobin (Hb) levels ≤ 13 g/dl (men) or ≤ 12 g/dl (women) received epoetin beta 450 IU/kg (∼30,000 IU) weekly until 4 weeks after their last platinum-based chemotherapy cycle.

Results

An anaemia prevention response [defined as patients with a Hb response (increase in Hb level > 1 g/dl from baseline) plus patients whose Hb levels remained ± 1 g/dl of baseline throughout the study] was observed in 234 patients (92%). Response to epoetin beta was rapid. Of the 159 patients achieving a Hb response, 139 (87%) had Hb levels > 1 g/dl of baseline within 4 weeks of treatment initiation. Mean Hb levels had improved from 10.8 ± 1.0 g/dl at baseline to 12.2 ± 1.8 g/dl by the final visit. Quality of life measured by linear analogue scale assessment significantly (< 0.01) improved in patients achieving a Hb response (= 159).

Conclusions

Epoetin beta effectively prevents anaemia in most patients with solid tumours receiving concurrent platinum-based chemotherapy.

Keywords

AnaemiaEpoetin betaPlatinum-based chemotherapySolid tumours

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Javier de Castro
    • 1
  • Amalio Ordóñez
    • 1
  • Dolores Isla
    • 2
  • Alfredo Sánchez
    • 3
  • Antonio Arrivi
    • 4
  • José Luis Manzano
    • 5
  • Manuel González Barón
    • 1
  1. 1.Servicio de Oncología MédicaHospital Universitario La Paz (Madrid)MadridSpain
  2. 2.Hospital Clínico Universitario de ZaragozaZaragozaSpain
  3. 3.Hospital Provincial de CastellónCastellonSpain
  4. 4.Hospital Son LlatzerPalma de MallorcaSpain
  5. 5.Hospital German Trias i PujolBarcelonaSpain