Cancer Chemotherapy and Pharmacology

, Volume 51, Issue 1, pp 75–80

Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats

  • Rutao Cui
  • Jinchun He
  • Baoen Wang
  • Fukui Zhang
  • Guangyong Chen
  • Shanshan Yin
  • Hong Shen
Original Article

DOI: 10.1007/s00280-002-0532-5

Cite this article as:
Cui, R., He, J., Wang, B. et al. Cancer Chemother Pharmacol (2003) 51: 75. doi:10.1007/s00280-002-0532-5
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Abstract.

Astragalus membranaceus (AM) has been widely used for treating liver diseases in traditional Chinese medicine. Experimental evidence indicates that it has antitumor potential. In this study, the effect of AM on hepatocarcinogenesis induced by diethylnitrosamine (DEN), two-thirds partial hepatectomy, and 2-acetylaminofluorene (2-AAF) (DEN-PH-AAF) was evaluated using glutathione S-transferase placenta form (GST-P) as marker. First, rats were injected intraperitoneally (i.p.) with DEN (200 mg/kg in saline), a two-thirds partial hepatectomy was carried out 2 weeks later, and the rats were then placed on a basal diet containing 0.02% AAF from week 3 to week 8 to induce hepatocarcinogenesis. The rats were given AM (90 mg/kg or 180 mg/kg body weight) by gavage from week 3 to week 8 (treatment groups). The formation of GST-P-positive foci and the expression of GST-P protein and mRNA caused by DEN-PH-AAF were reduced in the treatment groups, which clearly suggests that AM is effective in delaying DEN-PH-AAF-induced hepatocarcinogenesis.

Astragalus membranaceus Bunge Chemical-induced hepatocarcinogenesis 

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Rutao Cui
    • 1
  • Jinchun He
    • 2
  • Baoen Wang
    • 1
  • Fukui Zhang
    • 1
  • Guangyong Chen
    • 3
  • Shanshan Yin
    • 1
  • Hong Shen
    • 1
  1. 1.Liver Research Center, Beijing Friendship Hospital, Capital University of Medical Sciences, 95th Yongan Road, Beijing 100050, China
  2. 2.Medical Analysis Department, First Education Hospital, Lanzhou Medical College, Lanzhou, Gansu 730000, China
  3. 3.Pathology Department, Beijing Friendship Hospital, Capital University of Medical Sciences, 95th Yongan Road, Beijing 100050, China
  4. 4.Molecular Carcinogenesis Unit, International Agency for Research on Cancer (IARC), 150 cours Albert-Thomas, 69372 Lyon, Cedex 08, France

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