CASE REPORT

Annals of Hematology

, Volume 74, Issue 2, pp 99-101

First online:

Cytomegalovirus-associated myelodysplasia and thrombocytopenia in an immunocompetent adult

  • M. MiyaharaAffiliated withDivision of Hematology, Department of Internal Medicine, Saga Medical School, Nabeshima 5–1–1, Saga 849, Japan
  • , Y. ShimamotoAffiliated withDivision of Hematology, Department of Internal Medicine, Saga Medical School, Nabeshima 5–1–1, Saga 849, Japan
  • , H. YamadaAffiliated withDivision of Hematology, Department of Internal Medicine, Saga Medical School, Nabeshima 5–1–1, Saga 849, Japan
  • , K. ShibataAffiliated withDivision of Hematology, Department of Internal Medicine, Saga Medical School, Nabeshima 5–1–1, Saga 849, Japan
  • , M. MatsuzakiAffiliated withDivision of Hematology, Department of Internal Medicine, Saga Medical School, Nabeshima 5–1–1, Saga 849, Japan
  • , K. OnoAffiliated withDivision of Hematology, Department of Internal Medicine, Saga Medical School, Nabeshima 5–1–1, Saga 849, Japan

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Abstract

 Myelodysplasia and severe thrombocytopenia in association with cytomegalovirus (CMV) infection in immunocompetent adults have rarely been reported. We describe a previously healthy man who developed severe thrombocytopenia with myelodysplastic changes of bone marrow and multiple autoimmune abnormalities following CMV infection. We also discuss possible mechanisms leading to myelodysplasia and thrombocytopenia in CMV infection. We believe that CMV infection should be considered in the differential diagnosis of myelodysplasia and acute thrombocytopenia.

Key words Adult Cytomegalovirus Myelodysplasia Thrombocytopenia