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Improved clinical outcomes for multiple myeloma patients treated at a single specialty clinic

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Abstract

Despite recent advances made in its treatment, multiple myeloma (MM) remains an incurable B cell malignancy. Thus, the objective for treating these patients is to prolong overall survival (OS) and preserve patients’ quality of life. We have analyzed data from 264 consecutive MM patients who had their initial visit between July 1, 2004 and December 1, 2014 and have received treatment in a single clinic specializing in MM. We determined their progression-free survival (PFS, OS, and 5-year OS). The PFS for frontline (n = 165 treatments), salvage (n = 980), and all treatments (n = 1145) were 13.9, 4.6, and 5.5 months, respectively. The median OS of all patients was 98 months with a 5-year survival of 74%. The results of this study show a marked improvement in OS for unselected MM patients compared with historical data. There were no significant differences in OS between patients with different International Staging System (ISS) stages. Younger patients (<65 years old) showed a longer OS. The results of this study should help physicians predict outcomes for MM patients and be encouraging for patients with this B cell malignancy.

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Authors and Affiliations

  1. Institute for Myeloma & Bone Cancer Research, 9201 W. Sunset Blvd., Suite 300, West Hollywood, CA, 90069, USA

    Ariana Berenson, Suzie Vardanyan, Michael David, James Wang, Nika Manik Harutyunyan, Jillian Gottlieb, Ran Halleluyan, Kyle A. Udd, Shahrooz Eshaghian & James R. Berenson

  2. James R. Berenson, MD, Inc., Institute for Myeloma & Bone Cancer Research, 9201 W. Sunset Blvd, Suite 310, West Hollywood, CA, USA

    James Wang, Kyle A. Udd, Youram Nassir, Benjamin Eades, Regina Swift & James R. Berenson

  3. Oncotherapeutics, 9201 W. Sunset Blvd, Suite 317, West Hollywood, CA, USA

    Tanya M. Spektor & James R. Berenson

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  1. Ariana Berenson
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  2. Suzie Vardanyan
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  3. Michael David
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  4. James Wang
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Correspondence to James R. Berenson.

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This study was conducted in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Conflict of interest

Dr. Berenson is a consultant and receives honoraria and research funding from Takeda, Onyx-Amgen, Amgen, Janssen, Celgene, and Bristol-Meyers-Squibb. Ms. Swift receives honoraria from Celgene, Takeda-Millennium, Bristol-Meyers-Squibb, and Onyx-Amgen.

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Berenson, A., Vardanyan, S., David, M. et al. Improved clinical outcomes for multiple myeloma patients treated at a single specialty clinic. Ann Hematol 96, 441–448 (2017). https://doi.org/10.1007/s00277-016-2888-3

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