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Calreticulin mutations are not present in patients with myeloproliferative chronic myelomonocytic leukemia

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References

  1. Vardiman JW, Bennett JM, Bain BJ, Baumann I, Thiele J, Orazi A (2008) Myelodysplastic/myeloproliferative neoplasm, unclassifiable. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al.(Edt) WHO classification of tumors of haematopoietic and lymphoid tissues. Lyon, France, pp 76–79

  2. Itzykson R, Kosmider O, Renneville A, Gelsi-Boyer V, Meggendorfer M, Morabito M, Berthon C, Adès L, Fenaux P, Beyne-Rauzy O, Vey N, Braun T, Haferlach T, Dreyfus F, Cross NC, Preudhomme C, Bernard OA, Fontenay M, Vainchenker W, Schnittger S, Birnbaum D, Droin N, Solary E (2013) Prognostic score including gene mutations in chronic myelomonocytic leukemia. J Clin Oncol 31:2428–2436

    Article  CAS  PubMed  Google Scholar 

  3. Klampfl T, Gisslinger H, Harutyunyan AS, Nivarthi H, Rumi E, Milosevic JD, Them NC, Berg T, Gisslinger B, Pietra D, Chen D, Vladimer GI, Bagienski K, Milanesi C, Casetti IC, Sant’Antonio E, Ferretti V, Elena C, Schischlik F, Cleary C, Six M, Schalling M, Schönegger A, Bock C, Malcovati L, Pascutto C, Superti-Furga G, Cazzola M, Kralovics R (2013) Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med 369:2379–2390

    Article  CAS  PubMed  Google Scholar 

  4. Nangalia J, Massie CE, Baxter EJ, Nice FL, Gundem G, Wedge DC, Avezov E, Li J, Kollmann K, Kent DG, Aziz A, Godfrey AL, Hinton J, Martincorena I, Van Loo P, Jones AV, Guglielmelli P, Tarpey P, Harding HP, Fitzpatrick JD, Goudie CT, Ortmann CA, Loughran SJ, Raine K, Jones DR, Butler AP, Teague JW, O’Meara S, McLaren S, Bianchi M, Silber Y, Dimitropoulou D, Bloxham D, Mudie L, Maddison M, Robinson B, Keohane C, Maclean C, Hill K, Orchard K, Tauro S, Du MQ, Greaves M, Bowen D, Huntly BJ, Harrison CN, Cross NC, Ron D, Vannucchi AM, Papaemmanuil E, Campbell PJ, Green AR (2013) Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med 369:2391–2405

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Rumi E, Pietra D, Ferretti V, Klampfl T, Harutyunyan AS, Milosevic JD, Them NC, Berg T, Elena C, Casetti IC, Milanesi C, Sant’antonio E, Bellini M, Fugazza E, Renna MC, Boveri E, Astori C, Pascutto C, Kralovics R, Cazzola M, Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators (2014) JAK2 or CALR mutation status defines subtypes of essential thrombocythemia with substantially different clinical course and outcomes. Blood 123:1544–1551

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Tefferi A, Lasho TL, Finke CM, Knudson RA, Ketterling R, Hanson CH, Maffioli M, Caramazza D, Passamonti F, Pardanani A (2014) CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons. Leukemia 28:1472–1477

    Article  CAS  PubMed  Google Scholar 

  7. Panagiota V, Thol F, Markus B, Fehse B, Alchalby H, Badbaran A, Lehmann U, Koenecke C, Shahswar R, Chaturvedi A, Stadler M, Eder M, Göhring G, Koenigsmann M, Kloos A, Trummer A, Schroeder T, Kobbe G, Thiede C, Platzbecker U, Schlegelberger B, Kreipe HH, Ganser A, Kröger N, Heuser M (2014) Prognostic effect of calreticulin mutations in patients with myelofibrosis after allogeneic hematopoietic stem cell transplantation. Leukemia 28:1552–1555

    Article  CAS  PubMed  Google Scholar 

  8. Hou HA, Kuo YY, Chou WC, Chen PH, Tien HF (2014) Calreticulin mutation was rarely detected in patients with myelodysplastic syndrome. Leukemia 28:1555–1557

    Article  CAS  PubMed  Google Scholar 

  9. Wang SA, Hasserjian RP, Fox PS, Rogers HJ, Geyer JT, Chabot-Richards D, Weinzierl E, Hatem J, Jaso J, Kanagal-Shamanna R, Stingo FC, Patel KP, Mehrotra M, Bueso-Ramos C, Young KH, Dinardo CD, Verstovsek S, Tiu RV, Bagg A, Hsi ED, Arber DA, Foucar K, Luthra R, Orazi A (2014) Atypical chronic myeloid leukemia is clinically distinct from unclassifiable myelodysplastic/myeloproliferative neoplasms. Blood 123:2645–2651

    Article  CAS  PubMed  Google Scholar 

  10. Heuser M, Panagiota V, Koenecke C, Fehse B, Alchalby H, Badbaran A, Shahswar R, Stadler M, Eder M, Göhring G, Trummer A, Schroeder T, Kobbe G, Thiede C, Platzbecker U, Schlegelberger B, Kroeger N, Ganser A, Thol F (2014) Low frequency of calreticulin mutations in MDS patients. Leukemia 28:1933–1934

    Article  CAS  PubMed  Google Scholar 

  11. Cazzola M, Kralovis R (2014) From Janus Kinase 2 to calreticulin: the clinically relevant genomic landscape of myelopreliferative neoplasms. Blood 123:3714–3719

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

Diana Domínguez, PI11/02519 grant, 2014SGR225 (GRE) Generalitat de Catalunya and RD12/0036/0029, are greatly acknowledged.

Conflict of interest

All authors report no conflicts of interest.

Authorship

LZ and BX were the principal investigators and took primary responsibility for the paper; EZ, UG, MA, RC, HP, CB, JS, DG, and BX recruited the patients (samples and/or data); LZ, MC, SM, and LP performed the laboratory work for this study; UG, FM, and EF co-ordinated the research; and LZ and BX wrote the paper.

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Correspondence to Lurdes Zamora.

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Zamora, L., Germing, U., Cabezón, M. et al. Calreticulin mutations are not present in patients with myeloproliferative chronic myelomonocytic leukemia. Ann Hematol 94, 869–871 (2015). https://doi.org/10.1007/s00277-014-2262-2

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  • DOI: https://doi.org/10.1007/s00277-014-2262-2

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