Original Article

Annals of Hematology

, Volume 93, Issue 1, pp 13-32

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Treatment of invasive fungal infections in cancer patients—updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)

  • Sabine MoussetAffiliated withInterdisziplinäres Zentrum für Palliativmedizin, Agaplesion Markus Krankenhaus Email author 
  • , Dieter BuchheidtAffiliated withIII. Medizinische Klinik, Hämatologie und Internistische Onkologie, Universitätsmedizin Mannheim
  • , Werner HeinzAffiliated withSchwerpunkt Infektiologie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg
  • , Markus RuhnkeAffiliated withAbt. Onkologie und Hämatologie, Med. Klinik u. Poliklinik II, Campus Charité Mitte, Charité Universitätsmedizin
  • , Oliver A. CornelyAffiliated withDepartment I of Internal Medicine, Clinical Trials Centre Cologne, ZKS Köln, BMBF 01KN1106, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
  • , Gerlinde EgererAffiliated withMed. Klinik V, Universität Heidelberg
  • , William KrügerAffiliated withMedizinische Klinik C, Ferdinand-Sauerbruch-Strasse, Ernst-Moritz-Arndt-Universität
  • , Hartmut LinkAffiliated withKlinik für Innere Medizin I, Westpfalz-Klinikum Kaiserslautern
  • , Silke NeumannAffiliated withDepartment of Hematology and Oncology, Georg-August-University Göttingen
    • , Helmut OstermannAffiliated withDepartment Hematology and Oncology, University of Munich
    • , Jens PanseAffiliated withKlinik für Onkologie, Hämatologie und Stammzelltransplantation, Universitätsklinikum Aachen
    • , Olaf PenackAffiliated withMedizinische Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin
    • , Christina RiegerAffiliated withDepartment of Hematology/Oncology, University of Munich
    • , Martin Schmidt-HieberAffiliated withHELIOS Clinic Berlin Buch, Clinic for Hematology, Oncology and Tumorimmunology
    • , Gerda SillingAffiliated withDepartment of Internal Medicine A, Hematology/Oncology, University of Muenster
    • , Thomas SüdhoffAffiliated withII. Medizinische Klinik, Klinikum Passau
    • , Andrew J. UllmannAffiliated withSchwerpunkt Infektiologie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg
    • , Hans-Heinrich WolfAffiliated withDepartment of Oncology, University Hospital Halle
    • , Georg MaschmeyerAffiliated withHematology, Oncology and Palliative Care, Klinikum Ernst von Bergmann
    • , Angelika BöhmeAffiliated withONKOLOGIKUM, Frankfurt am Museumsufer


The Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) here presents its updated recommendations for the treatment of documented fungal infections. Invasive fungal infections are a main cause of morbidity and mortality in cancer patients undergoing intensive chemotherapy regimens. In recent years, new antifungal agents have been licensed, and agents already approved have been studied in new indications. The choice of the most appropriate antifungal treatment depends on the fungal species suspected or identified, the patient’s risk factors (e.g., length and depth of neutropenia), and the expected side effects. This guideline reviews the clinical studies that served as a basis for the following recommendations. All recommendations including the levels of evidence are summarized in tables to give the reader rapid access to the information.


Mycoses Antifungal agents Aspergillosis Invasive candidiasis Hematologic malignancies