Annals of Hematology

, Volume 92, Issue 12, pp 1685–1693

Predictive factors for rapid neutrophil and platelet engraftment after allogenic peripheral blood stem cell transplantation in patients with acute leukemia

  • Ho Sup Lee
  • Lee Chun Park
  • Eun Mi Lee
  • Seong Hoon Shin
  • Yang Soo Kim
  • Joon-Ho Moon
  • Won Sik Lee
  • Ho-Jin Shin
  • Mi Hyang Kim
  • Byeong Jin Ye
  • Joo-Seop Chung
Original Article

DOI: 10.1007/s00277-013-1847-5

Cite this article as:
Lee, H.S., Park, L.C., Lee, E.M. et al. Ann Hematol (2013) 92: 1685. doi:10.1007/s00277-013-1847-5

Abstract

The aim of this study was to investigate predictive factors for rapid engraftment after allogeneic peripheral blood stem cell transplantation (alloPBSCT) in patients with acute leukemia. Two hundred sixty-two patients receiving alloPBSCT were analyzed. Subset analyses of donor stem cells were conducted using a flow cytometric method. The correlation between rapid engraftment of neutrophils, platelets, and donor stem cells doses, as well as other recipient and donor clinical factors, was analyzed. In univariate analysis, factors correlated with neutrophil engraftment (≥0.5 × 109/L) by day 12 were achievement of complete remission (CR) after induction chemotherapy (CR1) before hematopoietic cell transplantation (HCT) and high numbers of CD34+ cells, CD3+ T cells, and CD3+/CD4+ T cells. Factors correlated with platelet engraftment (≥20 × 109/L) by day 12 were achievement of CR1 before HCT, donor and recipient sex mismatch, and high numbers of mononuclear cells, CD34+ cells, CD3+ T cells, CD3+/CD4+ T cells, CD3+/CD8+ T cells, and CD56+ NK cells. In multivariate analysis, independent predictive factors for rapid neutrophil and platelet engraftment were CR1 before HCT (p < 0.001 and p = 0.002, respectively), high number of donor CD34+ cells (p = 0.005 and p < 0.001, respectively), and high number of CD3+ T cells (p = 0.005 and p = 0.001, respectively). In conclusion, achieving CR1 before HCT, as well as larger quantities of donor CD34+ and CD3+ T cells, may predict rapid neutrophil and platelet engraftment after PBSCT.

Keywords

Allogeneic peripheral blood stem cell transplantation Engraftment Neutrophil Platelet 

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Ho Sup Lee
    • 1
  • Lee Chun Park
    • 1
  • Eun Mi Lee
    • 1
  • Seong Hoon Shin
    • 1
  • Yang Soo Kim
    • 1
  • Joon-Ho Moon
    • 2
  • Won Sik Lee
    • 3
  • Ho-Jin Shin
    • 4
  • Mi Hyang Kim
    • 5
  • Byeong Jin Ye
    • 6
  • Joo-Seop Chung
    • 4
  1. 1.Department of Internal MedicineKosin University College of MedicineBusanSouth Korea
  2. 2.Department of HematologyKyungpook National University HospitalDaeguSouth Korea
  3. 3.Department of Internal MedicineBusan Paik HospitalBusanSouth Korea
  4. 4.Department of Internal Medicine, School of MedicineBusan National UniversityBusanSouth Korea
  5. 5.Department of Laboratory MedicineKosin University College of MedicineBusanSouth Korea
  6. 6.Department of Occupational and Environmental MedicineKosin University College of MedicineBusanSouth Korea

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