Annals of Hematology

, Volume 92, Issue 6, pp 731–737

Prevalence and incidence of anemia in the German Heinz Nixdorf Recall Study

Authors

    • Department of HematologyUniversity Hospital Essen
    • Institute of Medical Informatics, Biometry and EpidemiologyUniversity Hospital Essen
  • Jan Dürig
    • Department of HematologyUniversity Hospital Essen
  • Martina Broecker-Preuss
    • Department of Endocrinology Division of Laboratory MedicineUniversity Hospital Essen
  • Ulrich Dührsen
    • Department of HematologyUniversity Hospital Essen
  • Beate Bokhof
    • Institute of Medical Informatics, Biometry and EpidemiologyUniversity Hospital Essen
  • Raimund Erbel
    • West German Heart CenterUniversity Hospital Essen
  • Susanne Moebus
    • Institute of Medical Informatics, Biometry and EpidemiologyUniversity Hospital Essen
  • Karl-Heinz Jöckel
    • Institute of Medical Informatics, Biometry and EpidemiologyUniversity Hospital Essen
  • on behalf of the Heinz Nixdorf Recall Study Investigative Group
Original Article

DOI: 10.1007/s00277-013-1697-1

Cite this article as:
Eisele, L., Dürig, J., Broecker-Preuss, M. et al. Ann Hematol (2013) 92: 731. doi:10.1007/s00277-013-1697-1

Abstract

This study aims to determine prevalence and incidence of anemia in the general population in Germany and evaluate a potential role of serum-free light chains (FLC) as biomarker in anemia. The population-based Heinz Nixdorf Recall Study comprises 4,814 men and women aged 45–75 years. Hemoglobin <13 g/dl in men and <12 g/dl in women defined anemia. Laboratory data was used to classify cases into renal, iron deficiency (IDA), vitamin B12/folic acid deficiency, anemia of chronic disease (ACD), and unexplained anemia (UA). Follow-up data was available from annual questionnaires, death certificates, and 5-year follow-up visit (5-year FU). Anemia cases (152) were identified (prevalence 3.2 %, 95 % CI 2.7–3.7). In participants aged 65 or older, prevalence was 4.3 % (95 % CI 2.9–6.0) in both men and women. Main anemia subtypes were: IDA 19 %, ACD 25 %, and UA 44 %. Incidence increased with age and was 12.8/1,000 person-years and 10.9/1,000 person-years in men and women aged 65 or older, respectively. UA was characterized by elevated FLC. Participants with elevated FLC and high-sensitivity C-reactive protein (hsCRP) had an increased risk of anemia at 5-year FU. FLC—alone or in combination with hsCRP—may serve as biomarker indicating an increased risk of developing anemia.

Keywords

Anemia Prevalence Incidence Population-based Biomarker

Supplementary material

277_2013_1697_MOESM1_ESM.docx (566 kb)
ESM 1 (DOCX 565 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2013