Date: 25 Nov 2012
Splenectomy followed by administration of rituximab is useful to treat a patient with hairy cell leukemia-variant
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Hairy cell leukemia-variant (HCL-v) is a rare disease-category separated from hairy cell leukeimia (HCL) by the WHO classification . The prognosis, characterized by splenomegaly, is relatively poor among splenomegalic B cell disorders including HCL and splenic marginal zone lymphoma (SMZL) . Thus, a novel therapeutic modality has been explored for HCL-v patients.
Here, we show that splenectomy followed by rituximab monotherapy led to molecular complete response (CR) with an undetectable level of PCR-based immunoglobulin heavy-chain gene (PCR-based IgH) rearrangement in a patient with HCL-v.
A 67-year-old female presented with an abdominal mass. Computed tomography showed significant splenomegaly (Fig. 1a). Pancytepenia (WBC count, 1.88 × 109/μl; Hb, 10.8 g/dl; and platelet count, 121 × 109/μl) and atypical lymphocytes (4.0 %) were noted in peripheral blood. Hepatitis B virus antigen and hepatitis C virus antibody were negative. Soluble interleukin-2 receptor was 835 IU/...
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Quach H, Januszewicz H, Westerman D (2005) Complete remission of hairy cell leukemia variant (HCL-v) complicated by red cell aplasia post treatment with rituximab. Haematologica 90:e72–e73
- Splenectomy followed by administration of rituximab is useful to treat a patient with hairy cell leukemia-variant
Annals of Hematology
Volume 92, Issue 5 , pp 711-713
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- 1. Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan
- 2. Department of Pathology, Hiroshima University, Hiroshima, Japan
- 3. Department of Pathology, Kure Kyosai Hospital, Kure, Japan
- 4. Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan