Annals of Hematology

, Volume 91, Issue 12, pp 1897–1906

CD99 expression and newly diagnosed diffuse large B-cell lymphoma treated with rituximab-CHOP immunochemotherapy

  • Junshik Hong
  • Sanghui Park
  • Jinny Park
  • Seung Jun Jang
  • Hee Kyung Ahn
  • Sun Jin Sym
  • Eun Kyung Cho
  • Dong Bok Shin
  • Jae Hoon Lee
Original Article

DOI: 10.1007/s00277-012-1533-z

Cite this article as:
Hong, J., Park, S., Park, J. et al. Ann Hematol (2012) 91: 1897. doi:10.1007/s00277-012-1533-z

Abstract

In order to evaluate prognostic value of CD99 expression in patients with diffuse large B-cell lymphoma (DLBCL) who underwent treatment with rituximab-CHOP immunochemotherapy, immunohistochemistry for CD99/CD10/BCL-2/BCL-6/MUM-1 was performed on nodal DLBCL specimens from 70 patients. Patients were classified as either germinal center B-cell (GCB) subtype or non-GCB subtype according to the Muris algorithm. A superior 2-year event-free survival (EFS) was observed in patients with the GCB subgroup, compared to those with the non-GCB subgroup (p = 0.034). The distribution of CD99 expression (29 patients; 41.4 %) did not show deviation according to subtype and was not prognostic for survival in the entire patient population. Among patients with the GCB subgroup, better EFS and overall survival (OS) were observed in CD99+ patients, compared to CD99− patients. Conversely, among patients with the non-GCB subgroup, inferior EFS and OS were reported in CD99+ patients. Superior 2-year EFS (p = 0.004) and 2-year OS (p = 0.003) were observed in patients with GCB/CD99+ and non-GCB/CD99− compared to the others, and the combination classification was found to be an independent prognostic factor.

Keywords

CD99 Diffuse large B-cell lymphoma Prognosis Immunohistochemistry 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Junshik Hong
    • 1
  • Sanghui Park
    • 2
  • Jinny Park
    • 1
  • Seung Jun Jang
    • 1
  • Hee Kyung Ahn
    • 1
  • Sun Jin Sym
    • 1
  • Eun Kyung Cho
    • 1
  • Dong Bok Shin
    • 1
  • Jae Hoon Lee
    • 1
  1. 1.Department of Internal MedicineGachon University School of MedicineIncheonRepublic of Korea
  2. 2.Department of PathologyEwha Womans University School of MedicineSeoulRepublic of Korea