Annals of Hematology

, Volume 91, Issue 5, pp 767–774

A prospective survey of febrile events in hematological malignancies

  • L. Pagano
  • M. Caira
  • G. Rossi
  • M. Tumbarello
  • R. Fanci
  • M. G. Garzia
  • N. Vianelli
  • N. Filardi
  • P. De Fabritiis
  • A. Beltrame
  • M. Musso
  • A. Piccin
  • A. Cuneo
  • C. Cattaneo
  • T. Aloisi
  • M. Riva
  • G. Rossi
  • U. Salvadori
  • M. Brugiatelli
  • S. Sannicolò
  • M. Morselli
  • A. Bonini
  • P. Viale
  • A. Nosari
  • F. Aversa
  • for the Hema e-Chart Group, Italy
Original Article

DOI: 10.1007/s00277-011-1373-2

Cite this article as:
Pagano, L., Caira, M., Rossi, G. et al. Ann Hematol (2012) 91: 767. doi:10.1007/s00277-011-1373-2

Abstract

The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed by fungi (95 cases), and viruses (7 cases). Mixed agents were isolated in 32 episodes. The attributable mortality rate was 6.7% (58 FEs). No deaths were observed in viral infection or in the noninfectious groups, while 25 deaths were due to FUO, 16 to bacterial infections, 14 to fungal infections, and three to mixed infections. The Hema e-Chart provided a complete system for the epidemiological study of infectious complications in HMs.

Keywords

EpidemiologyHematological malignanciesFebrile eventsRegistry

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • L. Pagano
    • 1
  • M. Caira
    • 1
  • G. Rossi
    • 2
  • M. Tumbarello
    • 3
  • R. Fanci
    • 4
  • M. G. Garzia
    • 5
  • N. Vianelli
    • 6
  • N. Filardi
    • 7
  • P. De Fabritiis
    • 8
  • A. Beltrame
    • 9
  • M. Musso
    • 10
  • A. Piccin
    • 11
  • A. Cuneo
    • 12
  • C. Cattaneo
    • 2
  • T. Aloisi
    • 13
  • M. Riva
    • 14
  • G. Rossi
    • 15
  • U. Salvadori
    • 16
  • M. Brugiatelli
    • 17
  • S. Sannicolò
    • 18
  • M. Morselli
    • 19
  • A. Bonini
    • 20
  • P. Viale
    • 21
  • A. Nosari
    • 14
  • F. Aversa
    • 13
  • for the Hema e-Chart Group, Italy
  1. 1.Istituto di Ematologia, Università Cattolica del Sacro CuoreRomaItaly
  2. 2.U.O. Ematologia, Spedali CiviliBresciaItaly
  3. 3.Istituto di Malattie Infettive, Università Cattolica S. CuoreRomaItaly
  4. 4.Azienda Osp. Univ. Careggi, EmatologiaFirenzeItaly
  5. 5.Divisione di Ematologia Az. Osp. S. Camillo ForlaniniRomaItaly
  6. 6.Istituto Seragnoli, Università di BolognaBolognaItaly
  7. 7.Ematologia, Azienda Osp. Osp. S. CarloPotenzaItaly
  8. 8.Ematologia, Ospedale S. EugenioRomaItaly
  9. 9.U.O. Ematologia Pol. Univ. Tor VergataRomaItaly
  10. 10.Dipartimento di Ematoncologia ed Unità Trap. Mid. OsseoPalermoItaly
  11. 11.Divione di Ematologia, Ospedale Generale di BolzanoBolognaItaly
  12. 12.Istituto di Ematologia, Az. Osp. Univ. Arcispedale S. AnnaFerraraItaly
  13. 13.Istituto di Ematologia, Università di PerugiaPerugiaItaly
  14. 14.Divisione di Ematologia e Centro Trapianti Midollo, Ospedale Niguarda Ca’ GrandaMilanoItaly
  15. 15.Unità di Ematologia, IRCCS Casa Sollievo della SofferenzaSan Giovanni RotondoItaly
  16. 16.Divisione di Ematologia, Ospedale Civile “Ca Foncello”TrevisoItaly
  17. 17.Ematologia, Ospedale PapardoMessinaItaly
  18. 18.Divisione di Ematologia, Umberto IMestreItaly
  19. 19.Divisione di Ematologia, Policlinico Universitario di Modena e ReggioModenaItaly
  20. 20.Divisione di Ematologia, Arciospedale S. Maria NuovaReggio EmiliaItaly
  21. 21.Clinica di Malattie Infettive, Università di BolognaBolognaItaly