Review Article

Annals of Hematology

, 90:993

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

The impact of treatment, socio-demographic and clinical characteristics on health-related quality of life among Hodgkin’s and non-Hodgkin’s lymphoma survivors: a systematic review

  • Simone OerlemansAffiliated withResearch Department, Comprehensive Cancer Centre SouthCenter of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University Email author 
  • , Floortje MolsAffiliated withResearch Department, Comprehensive Cancer Centre SouthCenter of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University
  • , Marten R. NijzielAffiliated withInternal Medicine/Haemato-Oncology, Máxima Medical Centre
  • , Marnix LybeertAffiliated withDepartment of Radiation Oncology, Catharina Hospital
  • , Lonneke V. van de Poll-FranseAffiliated withResearch Department, Comprehensive Cancer Centre SouthCenter of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University

Abstract

Cancer survivors are at risk of experiencing adverse physical and psychosocial effects of their cancer and its treatment. Both Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL) survivors face problems that can affect their health-related quality of life (HRQoL). The authors systematically reviewed the literature on HRQoL among HL and NHL survivors. A PubMed and PsychINFO literature search for original articles published until May 2011 was performed. Twenty-four articles, which met the predefined inclusion criteria, were subjected to a quality checklist. HL survivors showed the most problems in (role) physical, social and cognitive functioning, general health, fatigue and financial problems. In addition, HL survivors treated with a combination of therapies, with older age and female sex reported worse HRQoL. NHL survivors showed the most problems in physical functioning, appetite loss, vitality and financial problems. Having had chemotherapy was negatively associated with HRQoL, but no differences in chemotherapy regimens were found. Furthermore, in NHL survivors not meeting public exercise guidelines, HRQoL is low but can be improved with more exercise. More research on the longitudinal comparison between HL and NHL survivors and healthy controls should be performed in order to better understand the long-term (side) effects of treatment on HRQoL and possibilities to alleviate these.

Keywords

Quality of life Hodgkin’s lymphoma Non-Hodgkin’s lymphoma Cancer treatment Cancer survivors