Annals of Hematology

, 90:1153

Hodgkin’s lymphoma—long-term outcome: an experience from a tertiary care cancer center in North India

Authors

  • Prasanth Ganesan
    • Department of Medical OncologyAll India Institute of Medical Sciences
    • Department of Medical OncologyAll India Institute of Medical Sciences
  • Vinod Raina
    • Department of Medical OncologyAll India Institute of Medical Sciences
  • Atul Sharma
    • Department of Medical OncologyAll India Institute of Medical Sciences
  • Sameer Bakhshi
    • Department of Medical OncologyAll India Institute of Medical Sciences
  • Vishnubhatla Sreenivas
    • Department of BiostatisticsAll India Institute of Medical Sciences
  • Malini Vijayaraghavan
    • Department of PathologyAll India Institute of Medical Sciences
  • Sanjay Thulkar
    • Department of RadiodiagnosisAll India Institute of Medical Sciences
Original Article

DOI: 10.1007/s00277-011-1262-8

Cite this article as:
Ganesan, P., Kumar, L., Raina, V. et al. Ann Hematol (2011) 90: 1153. doi:10.1007/s00277-011-1262-8

Abstract

Limited information is available from developing countries on long-term outcome of patients with Hodgkin’s lymphoma (HL). Between January 1998 and December 2005, 262 patients (age ≥15 years) underwent treatment. Patients’ median age was 30 years, ranging from 15 to 72 years. Male to female ratio was 2.8:1. B symptoms were present in 64% of patients. Seventy percent of patients had stage III and IV disease. Mixed cellularity (52.3%) was the most common histology followed by nodular sclerosis (38%). ABVD chemotherapy was used in 85% of the patients, and 50% received radiotherapy as consolidation. Following treatment 92% of patients achieved complete response. Five-year freedom from treatment failure (FFTF) and overall survival rate are 78.3% and 86.6% ± 0.02% (95% CI 80.0–93.2%), respectively. Stage at presentation, number of lymph node regions involved (≥3 vs ≤2), presence of B symptoms, and serum albumin (≥40 vs <40 g/L) were important determinants of FFTF. In a subset analysis of stage I and II HL patients, presence of bulky disease and pure infradiaphragmatic disease was associated with inferior outcome. On multivariate analysis involvement of three or more number of lymph node regions was a significant predictor of inferior freedom from treatment failure survival (hazard ratio 2.2, p < 0.01). Our analysis confirms excellent outcome for patients of Hodgkin’s lymphoma with results comparable to developed countries.

Keywords

Hodgkin’s lymphomaDeveloping countriesOutcomeSurvivalPrognostic factors

Copyright information

© Springer-Verlag 2011