Annals of Hematology

, Volume 90, Issue 8, pp 933–938

Impact of leukocytosis on thrombotic risk and survival in 532 patients with essential thrombocythemia: a retrospective study

  • Francesca Palandri
  • Nicola Polverelli
  • Lucia Catani
  • Emanuela Ottaviani
  • Michele Baccarani
  • Nicola Vianelli
Original Article

DOI: 10.1007/s00277-010-1154-3

Cite this article as:
Palandri, F., Polverelli, N., Catani, L. et al. Ann Hematol (2011) 90: 933. doi:10.1007/s00277-010-1154-3

Abstract

Established risk factors for thrombosis in essential thrombocythemia (ET) include age (≥60 years) and previous vascular events. Recently, also leukocytosis has been proposed in risk stratification of ET patients. We report a retrospective study on 532 ET patients followed for a median of 7.6 years. Sixty-four patients (12%) developed 95 thrombotic events during follow-up. Together with the high-risk condition, a white blood cell (WBC) value above 11 × 109/L, corresponding to the fourth percentile value, significantly correlated with a higher thrombotic risk (p = 0.033) by Cox proportional hazards. Moreover, the cumulative risk of thrombosis was significantly higher in high-risk patients with WBC >11 × 109/L. JAK2 V617F mutation did not correlate with thrombosis. Overall, 123 (23%) patients died. Three independent parameters were noted as prognostic factors for survival in multivariate analysis: age >60 years, leukocytosis >11 × 109/L, and hemoglobin level below normal values. Based on these parameters, three groups of risk were defined, with significantly different survivals. Baseline leukocytosis correlated with a higher thrombotic risk in high-risk patients and identified a cohort of patients with worse survival.

Keywords

Essential thrombocythemiaLeukocytosisThrombotic riskSurvival

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Francesca Palandri
    • 1
  • Nicola Polverelli
    • 1
  • Lucia Catani
    • 1
  • Emanuela Ottaviani
    • 1
  • Michele Baccarani
    • 1
  • Nicola Vianelli
    • 1
    • 2
  1. 1.Department of Hematology and Oncology “L. e A. Seràgnoli”, St. Orsola-Malpighi HospitalUniversity of BolognaBolognaItaly
  2. 2.Institute of Hematology and Medical Oncology “L.& A. Seràgnoli”BolognaItaly