Annals of Hematology

, Volume 90, Issue 2, pp 159–164

High prevalence of hepatitis B and hepatitis C virus infections in Korean patients with hematopoietic malignancies

  • Jun Kang
  • Jeong Hyun Cho
  • Cheol Won Suh
  • Dae Ho Lee
  • Heung Bum Oh
  • Yong Hak Sohn
  • Hyun Sook Chi
  • Chan Jeong Park
  • Sung Soo Jang
  • Kyoo Hyung Lee
  • Je-Hwan Lee
  • Jung Hee Lee
  • Sang Wook Lee
  • Young Hwa Chung
  • Tae Hyup Kim
  • Hai-Rim Shin
  • Jooryung Huh
Original Article

DOI: 10.1007/s00277-010-1055-5

Cite this article as:
Kang, J., Cho, J.H., Suh, C.W. et al. Ann Hematol (2011) 90: 159. doi:10.1007/s00277-010-1055-5

Abstract

We performed a large case–control study (3,932 cases, 15,562 controls) to investigate the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) with hematopoietic malignancies in Korea, where HBV is endemic. HBV was present in 636 control patients (4.1%), 333 lymphoma patients (12.4%), and 75 leukemia patients (6.0%). HCV infection was present in 173 control patients (1.1%), 76 lymphoma patients (2.8%), and 18 leukemia patients (1.4%). Co-infection of HBV and HCV was present in one (0.007%) control patient, seven lymphoma patients (0.3%), and one leukemia patient (0.08%). HBV infection was associated with increased risks for most subtypes of B and T/NK-cell lymphomas, Hodgkin’s lymphoma, and acute myeloid leukemia. HCV infection was associated with increased risks for diffuse large B cell lymphoma, extranodal marginal zone B cell lymphoma, peripheral T cell lymphoma, and acute lymphoid leukemia B cell early pre-B type. HBV seems to have a more important role than HCV in the pathogenesis of specific hematologic malignancies in Korea.

Keywords

Case–control study Hepatitis B virus Hepatitis C virus Hematopoietic malignancy 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Jun Kang
    • 1
  • Jeong Hyun Cho
    • 1
  • Cheol Won Suh
    • 2
  • Dae Ho Lee
    • 2
  • Heung Bum Oh
    • 3
  • Yong Hak Sohn
    • 3
  • Hyun Sook Chi
    • 3
  • Chan Jeong Park
    • 3
  • Sung Soo Jang
    • 3
  • Kyoo Hyung Lee
    • 4
  • Je-Hwan Lee
    • 4
  • Jung Hee Lee
    • 4
  • Sang Wook Lee
    • 5
  • Young Hwa Chung
    • 6
  • Tae Hyup Kim
    • 7
  • Hai-Rim Shin
    • 8
  • Jooryung Huh
    • 1
  1. 1.Department of PathologyUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulSouth Korea
  2. 2.Department of OncologyUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulSouth Korea
  3. 3.Department of Laboratory MedicineUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulSouth Korea
  4. 4.Department of HematologyUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulSouth Korea
  5. 5.Department of Radiation OncologyUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulSouth Korea
  6. 6.Department of GastroenterologyUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulSouth Korea
  7. 7.Department of Health MedicineUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulSouth Korea
  8. 8.Departments of Biostatistics and Epidemiology ClusterIARCLyonFrance

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