Annals of Hematology

, Volume 89, Supplement 1, pp 31–35

Mechanisms of platelet recovery in ITP associated with therapy

Basic Science

DOI: 10.1007/s00277-010-0916-2

Cite this article as:
Pang, S.J.Y. & Lazarus, A.H. Ann Hematol (2010) 89: 31. doi:10.1007/s00277-010-0916-2

Abstract

Immune thrombocytopenia (ITP) is an autoimmune disease primarily characterized by increased clearance of auto-antibody-sensitized platelets by Fc-receptor-bearing macrophages in the spleen and liver. It has been classically accepted that antibody-mediated platelet destruction is Fc dependent. Recent studies, however, may also indicate the involvement of Fc-independent pathways of platelet destruction. Current treatment options work by immunosuppression (e.g., corticosteroids), immunomodulation (e.g., IVIg and anti-D), or removal of the platelet destruction site (splenectomy) in ITP. This review will discuss the mechanisms of action of these and other treatments for ITP.

Keywords

ITPTherapyIVIgAnti-DCorticosteroidsSplenectomyHelicobacter pylori

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.The Canadian Blood ServicesTorontoCanada
  2. 2.The Keenan Research CentreLi Ka Shing Knowledge Institute of St Michael’s HospitalTorontoCanada
  3. 3.The Toronto Platelet Immunobiology Group and The Departments of MedicineLaboratory Medicine & Pathobiology of the University of TorontoTorontoCanada
  4. 4.St. Michael’s HospitalTorontoCanada