Annals of Hematology

, Volume 89, Supplement 1, pp 37–44

Animal models of immune thrombocytopenia (ITP)

Basic Science

DOI: 10.1007/s00277-009-0882-8

Cite this article as:
Semple, J.W. Ann Hematol (2010) 89: 37. doi:10.1007/s00277-009-0882-8

Abstract

With regards to research animal models related to immune thrombocytopenia (ITP), there is an extensive literature of over 300 publications published since 1959. It appears that many of these models either confirm what has been found in human ITP or, in some instances, are the first to describe a phenomenon related to ITP that is still of relevance today in human medicine. These models will undoubtedly play a significant role in the future research of human ITP particularly related to understanding of the pathogenesis of the disorder and the development of novel therapeutics. This review will highlight some of the major animal models utilized for ITP research and will present a somewhat historical aspect of the subject.

Keywords

Immune thrombocytopeniaITPChronic ITPAnimal modelsDrug-induced ITPSecondary ITP

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Toronto Platelet Immunobiology Group, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Canadian Blood Services, Departments of Pharmacology, Medicine and Laboratory Medicine and PathobiologyUniversity of TorontoTorontoCanada