Annals of Hematology

, Volume 88, Issue 10, pp 937–941

Bulky extramedullary hematopoiesis is not a rare complication of congenital dyserythropoietic anemia

  • Hermann Heimpel
  • Ulrich Dührsen
  • P. Hofbauer
  • V. Rigamonti-Wermlinger
  • Ernst-Dietrich Kreuser
  • Klaus Schwarz
  • Max Solenthaler
  • S. Pauls
Original Article

DOI: 10.1007/s00277-009-0735-5

Cite this article as:
Heimpel, H., Dührsen, U., Hofbauer, P. et al. Ann Hematol (2009) 88: 937. doi:10.1007/s00277-009-0735-5
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Abstract

Bulky extramedullary hematopoiesis, usually detected in the thorax by imaging techniques, is a well-known complication in many types of congenital anemias. Here, we describe 12 cases of congenital dyserythropoietic anemia with extramedullary hematopoiesis which was always located in the paravertebral space of the thoracic spine and in other paraspinal regions in a few cases. All bulks were originally detected in chest radiographs and confirmed by imaging techniques such as computed tomography and/or magnetic resonance imaging. In some cases, thoracotomy was performed for suspected malignancy. Although the true prevalence is not known, paravertebral masses in patients with CDA of any type are not uncommon and should be the first differential diagnosis considered when masses adjacent to the spine are detected in this disorder.

Keywords

Congenital dyserythropoietic anemia Extramedullary hematopoiesis Imaging techniques 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Hermann Heimpel
    • 1
  • Ulrich Dührsen
    • 2
  • P. Hofbauer
    • 3
  • V. Rigamonti-Wermlinger
    • 4
  • Ernst-Dietrich Kreuser
    • 5
  • Klaus Schwarz
    • 6
  • Max Solenthaler
    • 4
  • S. Pauls
    • 7
  1. 1.Medizinische Klinik IIIUniversitätsklinikum UlmUlmGermany
  2. 2.Klinik für HämatologieUniversität EssenEssenGermany
  3. 3.Fachpraxis für LungenkrankheitenWeinheimGermany
  4. 4.Abteilung für Hämatologie and Hämatologisches ZentralaboratoratoriumUniversitätsklinik und Universität BernBernSwitzerland
  5. 5.Klinik für OnkologieKrankenhaus der barmherzigen BrüderRegensburgGermany
  6. 6.Institut für klinische Transfusionsmedizin und Immungenetik und Institut für TransfusionsmedizinUniversitätsklinikum UlmUlmGermany
  7. 7.Klinik für Diagnostische und Interventionelle RadiologieUniversitätsklinikum UlmUlmGermany

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