Annals of Hematology

, Volume 88, Issue 8, pp 785–788

Does regular blood transfusion prevent progression of cerebrovascular lesions in children with sickle cell disease?

  • Valentine Brousse
  • Lucie Hertz-Pannier
  • Yann Consigny
  • Jean-Louis Bresson
  • Robert Girot
  • Elsa Mirre
  • Gérard Lenoir
  • Mariane de Montalembert
Original Article

DOI: 10.1007/s00277-008-0670-x

Cite this article as:
Brousse, V., Hertz-Pannier, L., Consigny, Y. et al. Ann Hematol (2009) 88: 785. doi:10.1007/s00277-008-0670-x
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Abstract

A retrospective study was conducted to assess changes in cerebrovascular lesions, as assessed by magnetic resonance (MR) imaging and angiography in 18 children with sickle cell disease (SCD) receiving optimised chronic transfusions for primary stroke prevention (abnormal transcranial Doppler flow, nine patients, median follow-up 14.3 months (range, 7.9–48.9)) or secondary stroke prevention (nine patients, median follow-up 59.6 months (range, 11.0–127.9)). An experienced neuroradiologist blinded to patient data reviewed the 41 MR scans (median/patient, three (2–4)). Standard scores were used to evaluate parenchymal and vascular abnormalities at baseline and last follow-up. Within-patient score changes evaluated using Wilcoxon’s paired rank test indicated lesion progression in the secondary-prevention group (p = 0.027). Optimised transfusion therapy does not prevent progression of cerebral vasculopathy in SCD children with a history of stroke.

Keywords

Sickle cell disease Stroke Transfusion Brain imaging 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Valentine Brousse
    • 1
    • 2
  • Lucie Hertz-Pannier
    • 3
    • 4
  • Yann Consigny
    • 5
  • Jean-Louis Bresson
    • 6
  • Robert Girot
    • 7
  • Elsa Mirre
    • 2
  • Gérard Lenoir
    • 2
  • Mariane de Montalembert
    • 1
    • 2
  1. 1.Reference Centre for HaemoglobinopathiesHôpital Necker, APHPParisFrance
  2. 2.Paediatrics DepartmentHôpital Necker Enfants MaladesParisFrance
  3. 3.Department of Paediatric RadiologyHôpital Necker, APHPParisFrance
  4. 4.INSERM U663, Paris Descartes UniversityParisFrance
  5. 5.Department of HepatologyHôpital Beaujon, APHPParisFrance
  6. 6.Clinical Research UnitHôpital Necker, APHPParisFrance
  7. 7.Haematology LaboratoryHôpital Tenon, APHPParisFrance

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